A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.

Sewoon Han, Ji Jing Yan, Yoojin Shin, Jessie J. Jeon, Jihee Won, Hyo Eun Jeong, Roger D. Kamm, Young Joon Kim, Seok Chung

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.

Original languageEnglish
Pages (from-to)3861-3865
Number of pages5
JournalLab on a chip
Volume12
Issue number20
DOIs
Publication statusPublished - 2012 Oct 21

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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