A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation

Ashkan Vaziri, Hyungsuk Lee, Roger D. Kamm, Mohammad R.Kaazempur Mofrad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.

Original languageEnglish
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Pages1108-1109
Number of pages2
Publication statusPublished - 2005 Dec 1
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: 2005 Jun 222005 Jun 26

Publication series

NameProceedings of the 2005 Summer Bioengineering Conference
Volume2005

Other

Other2005 Summer Bioengineering Conference
CountryUnited States
CityVail, CO
Period05/6/2205/6/26

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Vaziri, A., Lee, H., Kamm, R. D., & Mofrad, M. R. K. (2005). A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. In Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC (pp. 1108-1109). (Proceedings of the 2005 Summer Bioengineering Conference; Vol. 2005).