A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation

Ashkan Vaziri, Hyungsuk Lee, Roger D. Kamm, Mohammad R.Kaazempur Mofrad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.

Original languageEnglish
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Pages1108-1109
Number of pages2
Publication statusPublished - 2005 Dec 1
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: 2005 Jun 222005 Jun 26

Publication series

NameProceedings of the 2005 Summer Bioengineering Conference
Volume2005

Other

Other2005 Summer Bioengineering Conference
CountryUnited States
CityVail, CO
Period05/6/2205/6/26

Fingerprint

Indentation
Atomic force microscopy
Mechanics
Membranes
Loads (forces)
Materials properties

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Vaziri, A., Lee, H., Kamm, R. D., & Mofrad, M. R. K. (2005). A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. In Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC (pp. 1108-1109). (Proceedings of the 2005 Summer Bioengineering Conference; Vol. 2005).
Vaziri, Ashkan ; Lee, Hyungsuk ; Kamm, Roger D. ; Mofrad, Mohammad R.Kaazempur. / A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. 2005. pp. 1108-1109 (Proceedings of the 2005 Summer Bioengineering Conference).
@inproceedings{92755e79466a42729180a83f8ee832d8,
title = "A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation",
abstract = "A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.",
author = "Ashkan Vaziri and Hyungsuk Lee and Kamm, {Roger D.} and Mofrad, {Mohammad R.Kaazempur}",
year = "2005",
month = "12",
day = "1",
language = "English",
isbn = "0974249211",
series = "Proceedings of the 2005 Summer Bioengineering Conference",
pages = "1108--1109",
booktitle = "Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC",

}

Vaziri, A, Lee, H, Kamm, RD & Mofrad, MRK 2005, A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. in Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. Proceedings of the 2005 Summer Bioengineering Conference, vol. 2005, pp. 1108-1109, 2005 Summer Bioengineering Conference, Vail, CO, United States, 05/6/22.

A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. / Vaziri, Ashkan; Lee, Hyungsuk; Kamm, Roger D.; Mofrad, Mohammad R.Kaazempur.

Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. 2005. p. 1108-1109 (Proceedings of the 2005 Summer Bioengineering Conference; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation

AU - Vaziri, Ashkan

AU - Lee, Hyungsuk

AU - Kamm, Roger D.

AU - Mofrad, Mohammad R.Kaazempur

PY - 2005/12/1

Y1 - 2005/12/1

N2 - A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.

AB - A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.

UR - http://www.scopus.com/inward/record.url?scp=33646563705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646563705&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33646563705

SN - 0974249211

SN - 9780974249216

T3 - Proceedings of the 2005 Summer Bioengineering Conference

SP - 1108

EP - 1109

BT - Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC

ER -

Vaziri A, Lee H, Kamm RD, Mofrad MRK. A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation. In Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. 2005. p. 1108-1109. (Proceedings of the 2005 Summer Bioengineering Conference).