A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

R. A. Spritz, K. M. Strunk, Seung-Taek Lee, J. M. Lu-Kuo, D. C. Ward, D. Le Paslier, M. R. Altherr, T. E. Dorman, D. T. Moir

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Abstract

We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalGenomics
Volume22
Issue number2
DOIs
Publication statusPublished - 1994 Jul 15

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Yeast Artificial Chromosomes
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Piebaldism
Chromosomes
Sequence Tagged Sites
Chromosomes, Human, Pair 4
Melanocytes
Human Chromosomes
Multigene Family
Genes
Ligands
Mutation
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Spritz, R. A. ; Strunk, K. M. ; Lee, Seung-Taek ; Lu-Kuo, J. M. ; Ward, D. C. ; Le Paslier, D. ; Altherr, M. R. ; Dorman, T. E. ; Moir, D. T. / A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. In: Genomics. 1994 ; Vol. 22, No. 2. pp. 431-436.
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Spritz, RA, Strunk, KM, Lee, S-T, Lu-Kuo, JM, Ward, DC, Le Paslier, D, Altherr, MR, Dorman, TE & Moir, DT 1994, 'A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12', Genomics, vol. 22, no. 2, pp. 431-436. https://doi.org/10.1006/geno.1994.1405

A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. / Spritz, R. A.; Strunk, K. M.; Lee, Seung-Taek; Lu-Kuo, J. M.; Ward, D. C.; Le Paslier, D.; Altherr, M. R.; Dorman, T. E.; Moir, D. T.

In: Genomics, Vol. 22, No. 2, 15.07.1994, p. 431-436.

Research output: Contribution to journalArticle

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T1 - A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

AU - Spritz, R. A.

AU - Strunk, K. M.

AU - Lee, Seung-Taek

AU - Lu-Kuo, J. M.

AU - Ward, D. C.

AU - Le Paslier, D.

AU - Altherr, M. R.

AU - Dorman, T. E.

AU - Moir, D. T.

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N2 - We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

AB - We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

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