Abdominal Aortic Calcification in Living Kidney Donors

Y. E. Yoon, W. K. Han, H. H. Lee, M. Y. Chang, K. H. Huh, D. C. Jung, Y. S. Kim, Y. T. Oh

Research output: Contribution to journalArticle

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Abstract

Objective This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. Methods Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. Results The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P <.001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P =.035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P =.022), tubular atrophy (62.5% vs 33.1%; P =.002), and a higher nephrosclerosis score (P =.002). Conclusions Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.

Original languageEnglish
Pages (from-to)720-724
Number of pages5
JournalTransplantation Proceedings
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Apr 1

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Nephrosclerosis
Living Donors
Tissue Donors
Kidney
Recovery of Function
Atrophy
Arteriosclerosis
Abdominal Aorta
Nephrectomy
Glomerular Filtration Rate
Fibrosis
Biomarkers
Observation
Biopsy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Yoon, Y. E., Han, W. K., Lee, H. H., Chang, M. Y., Huh, K. H., Jung, D. C., ... Oh, Y. T. (2016). Abdominal Aortic Calcification in Living Kidney Donors. Transplantation Proceedings, 48(3), 720-724. https://doi.org/10.1016/j.transproceed.2016.02.037
Yoon, Y. E. ; Han, W. K. ; Lee, H. H. ; Chang, M. Y. ; Huh, K. H. ; Jung, D. C. ; Kim, Y. S. ; Oh, Y. T. / Abdominal Aortic Calcification in Living Kidney Donors. In: Transplantation Proceedings. 2016 ; Vol. 48, No. 3. pp. 720-724.
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abstract = "Objective This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. Methods Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. Results The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P <.001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P =.035). Donors with AAC were more likely to have glomerulosclerosis (50.0{\%} vs 29.1{\%}; P =.022), tubular atrophy (62.5{\%} vs 33.1{\%}; P =.002), and a higher nephrosclerosis score (P =.002). Conclusions Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.",
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Abdominal Aortic Calcification in Living Kidney Donors. / Yoon, Y. E.; Han, W. K.; Lee, H. H.; Chang, M. Y.; Huh, K. H.; Jung, D. C.; Kim, Y. S.; Oh, Y. T.

In: Transplantation Proceedings, Vol. 48, No. 3, 01.04.2016, p. 720-724.

Research output: Contribution to journalArticle

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T1 - Abdominal Aortic Calcification in Living Kidney Donors

AU - Yoon, Y. E.

AU - Han, W. K.

AU - Lee, H. H.

AU - Chang, M. Y.

AU - Huh, K. H.

AU - Jung, D. C.

AU - Kim, Y. S.

AU - Oh, Y. T.

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N2 - Objective This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. Methods Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. Results The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P <.001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P =.035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P =.022), tubular atrophy (62.5% vs 33.1%; P =.002), and a higher nephrosclerosis score (P =.002). Conclusions Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.

AB - Objective This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. Methods Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. Results The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P <.001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P =.035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P =.022), tubular atrophy (62.5% vs 33.1%; P =.002), and a higher nephrosclerosis score (P =.002). Conclusions Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.

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