Abdominal seeding of renal cell carcinoma

radiologic, pathologic, and prognostic features

Seung Hyun Park, Young Taik Oh, Dae Chul Jung, Namhoon Cho, Youngdeuk Choi, Sung Yoon Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: We analyzed radiologic and histologic characteristics, and prognosis of abdominal seeding from renal cell carcinoma (RCC). Methods: Consecutive 25 patients with RCC and histologically or radiologically diagnosed abdominal seeding were analyzed. No patient had another type of malignancy. Histologic subtype, Fuhrman grade, sarcomatoid differentiation, and T-stage of primary tumors were assessed. Pre- or postoperative presentation of seeding was investigated. Median survival time and RCC-specific survival rates were evaluated. Results: Of 25 patients, 15 (60%) died and 4 (16%) were hopelessly discharged (median follow-up time, 6 months; range 1–62 months). Histologic subtypes were clear cell (76%, 19/25), papillary (16%, 4/25), chromophobe (4%, 1/25), and poorly differentiated (4%, 1/25). Fuhrman grades were 4 (48%, 12/25), 3 (36%, 9/25), 2 (12%, 3/25), and unknown (4%, 1/25). T-stage of the four patients with grade 2 or unknown was 3a. Sarcomatoid differentiation and postoperative occurrence were found in 32% (8/25) and 80% (20/25), respectively. Median survival time was 13 months, and 1-year, 2-year, and 3-year RCC-specific survival rates were 51%, 41%, and 31%, respectively. Conclusion: Abdominal seeding may occur in various subtypes of RCC with high Fuhrman grade including sarcomatoid differentiation or high T-stage, and appears to be related to poor prognosis.

Original languageEnglish
Pages (from-to)1510-1516
Number of pages7
JournalAbdominal Radiology
Volume42
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Renal Cell Carcinoma
Survival Rate
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

Park, Seung Hyun ; Oh, Young Taik ; Jung, Dae Chul ; Cho, Namhoon ; Choi, Youngdeuk ; Park, Sung Yoon. / Abdominal seeding of renal cell carcinoma : radiologic, pathologic, and prognostic features. In: Abdominal Radiology. 2017 ; Vol. 42, No. 5. pp. 1510-1516.
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abstract = "Purpose: We analyzed radiologic and histologic characteristics, and prognosis of abdominal seeding from renal cell carcinoma (RCC). Methods: Consecutive 25 patients with RCC and histologically or radiologically diagnosed abdominal seeding were analyzed. No patient had another type of malignancy. Histologic subtype, Fuhrman grade, sarcomatoid differentiation, and T-stage of primary tumors were assessed. Pre- or postoperative presentation of seeding was investigated. Median survival time and RCC-specific survival rates were evaluated. Results: Of 25 patients, 15 (60{\%}) died and 4 (16{\%}) were hopelessly discharged (median follow-up time, 6 months; range 1–62 months). Histologic subtypes were clear cell (76{\%}, 19/25), papillary (16{\%}, 4/25), chromophobe (4{\%}, 1/25), and poorly differentiated (4{\%}, 1/25). Fuhrman grades were 4 (48{\%}, 12/25), 3 (36{\%}, 9/25), 2 (12{\%}, 3/25), and unknown (4{\%}, 1/25). T-stage of the four patients with grade 2 or unknown was 3a. Sarcomatoid differentiation and postoperative occurrence were found in 32{\%} (8/25) and 80{\%} (20/25), respectively. Median survival time was 13 months, and 1-year, 2-year, and 3-year RCC-specific survival rates were 51{\%}, 41{\%}, and 31{\%}, respectively. Conclusion: Abdominal seeding may occur in various subtypes of RCC with high Fuhrman grade including sarcomatoid differentiation or high T-stage, and appears to be related to poor prognosis.",
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Abdominal seeding of renal cell carcinoma : radiologic, pathologic, and prognostic features. / Park, Seung Hyun; Oh, Young Taik; Jung, Dae Chul; Cho, Namhoon; Choi, Youngdeuk; Park, Sung Yoon.

In: Abdominal Radiology, Vol. 42, No. 5, 01.05.2017, p. 1510-1516.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Abdominal seeding of renal cell carcinoma

T2 - radiologic, pathologic, and prognostic features

AU - Park, Seung Hyun

AU - Oh, Young Taik

AU - Jung, Dae Chul

AU - Cho, Namhoon

AU - Choi, Youngdeuk

AU - Park, Sung Yoon

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Purpose: We analyzed radiologic and histologic characteristics, and prognosis of abdominal seeding from renal cell carcinoma (RCC). Methods: Consecutive 25 patients with RCC and histologically or radiologically diagnosed abdominal seeding were analyzed. No patient had another type of malignancy. Histologic subtype, Fuhrman grade, sarcomatoid differentiation, and T-stage of primary tumors were assessed. Pre- or postoperative presentation of seeding was investigated. Median survival time and RCC-specific survival rates were evaluated. Results: Of 25 patients, 15 (60%) died and 4 (16%) were hopelessly discharged (median follow-up time, 6 months; range 1–62 months). Histologic subtypes were clear cell (76%, 19/25), papillary (16%, 4/25), chromophobe (4%, 1/25), and poorly differentiated (4%, 1/25). Fuhrman grades were 4 (48%, 12/25), 3 (36%, 9/25), 2 (12%, 3/25), and unknown (4%, 1/25). T-stage of the four patients with grade 2 or unknown was 3a. Sarcomatoid differentiation and postoperative occurrence were found in 32% (8/25) and 80% (20/25), respectively. Median survival time was 13 months, and 1-year, 2-year, and 3-year RCC-specific survival rates were 51%, 41%, and 31%, respectively. Conclusion: Abdominal seeding may occur in various subtypes of RCC with high Fuhrman grade including sarcomatoid differentiation or high T-stage, and appears to be related to poor prognosis.

AB - Purpose: We analyzed radiologic and histologic characteristics, and prognosis of abdominal seeding from renal cell carcinoma (RCC). Methods: Consecutive 25 patients with RCC and histologically or radiologically diagnosed abdominal seeding were analyzed. No patient had another type of malignancy. Histologic subtype, Fuhrman grade, sarcomatoid differentiation, and T-stage of primary tumors were assessed. Pre- or postoperative presentation of seeding was investigated. Median survival time and RCC-specific survival rates were evaluated. Results: Of 25 patients, 15 (60%) died and 4 (16%) were hopelessly discharged (median follow-up time, 6 months; range 1–62 months). Histologic subtypes were clear cell (76%, 19/25), papillary (16%, 4/25), chromophobe (4%, 1/25), and poorly differentiated (4%, 1/25). Fuhrman grades were 4 (48%, 12/25), 3 (36%, 9/25), 2 (12%, 3/25), and unknown (4%, 1/25). T-stage of the four patients with grade 2 or unknown was 3a. Sarcomatoid differentiation and postoperative occurrence were found in 32% (8/25) and 80% (20/25), respectively. Median survival time was 13 months, and 1-year, 2-year, and 3-year RCC-specific survival rates were 51%, 41%, and 31%, respectively. Conclusion: Abdominal seeding may occur in various subtypes of RCC with high Fuhrman grade including sarcomatoid differentiation or high T-stage, and appears to be related to poor prognosis.

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U2 - 10.1007/s00261-016-1029-8

DO - 10.1007/s00261-016-1029-8

M3 - Article

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JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

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