Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression

Sung Im Do, Kyungeun Kim, Hyunjoo Lee, Hyun Soo Kim, Tae Gu Do, Jisup Yun, Dong Hoon Kim, Seoung Wan Chae, Yong Lai Park, Chan Heun Park, Jin Hee Sohn, Kyueng Whan Min, Jung Soo Pyo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cullin 1 (Cul1) is a rigid scaffold protein of a major class of E3 ubiquitin ligase, also known as the Skp1/cullin1/F-box (SCF) complex, which is involved in cell-cycle progression. The aberrant expression of Cul1 is involved in the dysfunction of SCF E3 ligase. Previous studies have revealed an association between increased Cul1 expression and tumor progression and poor outcome in several different tumors. We constructed a tissue microarray containing 103 papillary carcinoma tissues of the thyroid and 66 normal thyroid tissues. Cul1 expression and Cyclin D1 expression were evaluated by immunohistochemistry staining, and the relationship between their expression and clinicopathological parameters were analyzed. Cytoplasmic expression of Cul1 was correlated with tumor occurrence (p < 0.001), N stage (p = 0.027), and Cyclin D1 expression (p < 0.001). Cyclin D1 expression showed a correlation with tumor occurrence (p < 0.001) and T stage (p = 0.009). On the other hand, nuclear expression of Cul1 showed a negative correlation with tumor occurrence (p < 0.001) and Cyclin D1 expression (p < 0.001). Cytoplasmic Cul1 expression was associated with tumor development and higher nodal metastasis status, supporting the idea that the SCF complex is involved in cell-cycle regulation and promotes cell proliferation. Nuclear expression of Cul1 showed inverse relationship between tumor aggressiveness factors. Our data suggest that the expression site of Cul1 may affect the function of the SFC complex and play a role in tumor progression.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalEndocrine Pathology
Volume25
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Cyclin D1
Neoplasms
Ubiquitin-Protein Ligases
Cell Cycle
Cullin 1
Papillary Thyroid cancer
Thyroid Gland
Immunohistochemistry
Cell Proliferation
Staining and Labeling
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Do, Sung Im ; Kim, Kyungeun ; Lee, Hyunjoo ; Kim, Hyun Soo ; Do, Tae Gu ; Yun, Jisup ; Kim, Dong Hoon ; Chae, Seoung Wan ; Park, Yong Lai ; Park, Chan Heun ; Sohn, Jin Hee ; Min, Kyueng Whan ; Pyo, Jung Soo. / Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression. In: Endocrine Pathology. 2014 ; Vol. 25, No. 3. pp. 282-287.
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title = "Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression",
abstract = "Cullin 1 (Cul1) is a rigid scaffold protein of a major class of E3 ubiquitin ligase, also known as the Skp1/cullin1/F-box (SCF) complex, which is involved in cell-cycle progression. The aberrant expression of Cul1 is involved in the dysfunction of SCF E3 ligase. Previous studies have revealed an association between increased Cul1 expression and tumor progression and poor outcome in several different tumors. We constructed a tissue microarray containing 103 papillary carcinoma tissues of the thyroid and 66 normal thyroid tissues. Cul1 expression and Cyclin D1 expression were evaluated by immunohistochemistry staining, and the relationship between their expression and clinicopathological parameters were analyzed. Cytoplasmic expression of Cul1 was correlated with tumor occurrence (p < 0.001), N stage (p = 0.027), and Cyclin D1 expression (p < 0.001). Cyclin D1 expression showed a correlation with tumor occurrence (p < 0.001) and T stage (p = 0.009). On the other hand, nuclear expression of Cul1 showed a negative correlation with tumor occurrence (p < 0.001) and Cyclin D1 expression (p < 0.001). Cytoplasmic Cul1 expression was associated with tumor development and higher nodal metastasis status, supporting the idea that the SCF complex is involved in cell-cycle regulation and promotes cell proliferation. Nuclear expression of Cul1 showed inverse relationship between tumor aggressiveness factors. Our data suggest that the expression site of Cul1 may affect the function of the SFC complex and play a role in tumor progression.",
author = "Do, {Sung Im} and Kyungeun Kim and Hyunjoo Lee and Kim, {Hyun Soo} and Do, {Tae Gu} and Jisup Yun and Kim, {Dong Hoon} and Chae, {Seoung Wan} and Park, {Yong Lai} and Park, {Chan Heun} and Sohn, {Jin Hee} and Min, {Kyueng Whan} and Pyo, {Jung Soo}",
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Do, SI, Kim, K, Lee, H, Kim, HS, Do, TG, Yun, J, Kim, DH, Chae, SW, Park, YL, Park, CH, Sohn, JH, Min, KW & Pyo, JS 2014, 'Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression', Endocrine Pathology, vol. 25, no. 3, pp. 282-287. https://doi.org/10.1007/s12022-014-9321-z

Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression. / Do, Sung Im; Kim, Kyungeun; Lee, Hyunjoo; Kim, Hyun Soo; Do, Tae Gu; Yun, Jisup; Kim, Dong Hoon; Chae, Seoung Wan; Park, Yong Lai; Park, Chan Heun; Sohn, Jin Hee; Min, Kyueng Whan; Pyo, Jung Soo.

In: Endocrine Pathology, Vol. 25, No. 3, 01.01.2014, p. 282-287.

Research output: Contribution to journalArticle

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T1 - Aberrant Expression Pattern and Location of Cullin 1 are Associated With the Development of Papillary Carcinoma in Thyroid and Cyclin D1 Expression

AU - Do, Sung Im

AU - Kim, Kyungeun

AU - Lee, Hyunjoo

AU - Kim, Hyun Soo

AU - Do, Tae Gu

AU - Yun, Jisup

AU - Kim, Dong Hoon

AU - Chae, Seoung Wan

AU - Park, Yong Lai

AU - Park, Chan Heun

AU - Sohn, Jin Hee

AU - Min, Kyueng Whan

AU - Pyo, Jung Soo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Cullin 1 (Cul1) is a rigid scaffold protein of a major class of E3 ubiquitin ligase, also known as the Skp1/cullin1/F-box (SCF) complex, which is involved in cell-cycle progression. The aberrant expression of Cul1 is involved in the dysfunction of SCF E3 ligase. Previous studies have revealed an association between increased Cul1 expression and tumor progression and poor outcome in several different tumors. We constructed a tissue microarray containing 103 papillary carcinoma tissues of the thyroid and 66 normal thyroid tissues. Cul1 expression and Cyclin D1 expression were evaluated by immunohistochemistry staining, and the relationship between their expression and clinicopathological parameters were analyzed. Cytoplasmic expression of Cul1 was correlated with tumor occurrence (p < 0.001), N stage (p = 0.027), and Cyclin D1 expression (p < 0.001). Cyclin D1 expression showed a correlation with tumor occurrence (p < 0.001) and T stage (p = 0.009). On the other hand, nuclear expression of Cul1 showed a negative correlation with tumor occurrence (p < 0.001) and Cyclin D1 expression (p < 0.001). Cytoplasmic Cul1 expression was associated with tumor development and higher nodal metastasis status, supporting the idea that the SCF complex is involved in cell-cycle regulation and promotes cell proliferation. Nuclear expression of Cul1 showed inverse relationship between tumor aggressiveness factors. Our data suggest that the expression site of Cul1 may affect the function of the SFC complex and play a role in tumor progression.

AB - Cullin 1 (Cul1) is a rigid scaffold protein of a major class of E3 ubiquitin ligase, also known as the Skp1/cullin1/F-box (SCF) complex, which is involved in cell-cycle progression. The aberrant expression of Cul1 is involved in the dysfunction of SCF E3 ligase. Previous studies have revealed an association between increased Cul1 expression and tumor progression and poor outcome in several different tumors. We constructed a tissue microarray containing 103 papillary carcinoma tissues of the thyroid and 66 normal thyroid tissues. Cul1 expression and Cyclin D1 expression were evaluated by immunohistochemistry staining, and the relationship between their expression and clinicopathological parameters were analyzed. Cytoplasmic expression of Cul1 was correlated with tumor occurrence (p < 0.001), N stage (p = 0.027), and Cyclin D1 expression (p < 0.001). Cyclin D1 expression showed a correlation with tumor occurrence (p < 0.001) and T stage (p = 0.009). On the other hand, nuclear expression of Cul1 showed a negative correlation with tumor occurrence (p < 0.001) and Cyclin D1 expression (p < 0.001). Cytoplasmic Cul1 expression was associated with tumor development and higher nodal metastasis status, supporting the idea that the SCF complex is involved in cell-cycle regulation and promotes cell proliferation. Nuclear expression of Cul1 showed inverse relationship between tumor aggressiveness factors. Our data suggest that the expression site of Cul1 may affect the function of the SFC complex and play a role in tumor progression.

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