Aberration correction by nonlinear beam-mixing

Generation of a pseudo point sound source

Jongbum Seo, J. J. Choi, T. L. Hall, J. B. Fowlkes, M. O'Donnell, C. A. Cain

Research output: Contribution to journalConference article

Abstract

Nonlinear beam mixing with microbubbles was explored to create a pseudo point source for aberration correction of therapeutic ultrasound. A damping coefficient for a bubble driven by a dual frequency sound field was derived by revisiting Prosperetti's linearized damping model. As a result, the overall damping term for dual frequency was obtained by linear summation of two damping terms for each frequency. The numerical simulation based on the bubble model suggests that the most efficient bubble radius to generate a 1 MHz frequency from 4 MHz and 5 MHz sound sources is 2.6 - 3.0 μm. Furthermore, this size range constitutes the primary distribution of a specific ultrasound contrast agent: Optison (Amersham Health, Princeton, NJ). When a chamber of 0.1% diluted Optison was insonified by 4 MHz and 5 MHz sound beams with 80° incident angle between them, an approximately 100 Pa, 1 MHz difference frequency signal was measured approximately 10 cm away. In addition, the received 1 MHz difference frequency signal shows omnidirectional characteristics, even though the overlap zone of the two sound beams is on the order of the difference frequency wavelength. Therefore, the induced sound source can be considered as a pseudo point source and is expected to be useful for aberration correction for therapeutic ultrasound.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalProceedings - IEEE Ultrasonics Symposium
Volume1
Publication statusPublished - 2004 Dec 1
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: 2004 Aug 232004 Aug 27

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Aberrations
aberration
Damping
Acoustic waves
acoustics
Ultrasonics
damping
bubbles
Acoustic fields
point sources
Health
Wavelength
sound fields
Computer simulation
health
chambers
radii
coefficients
wavelengths
simulation

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Seo, J., Choi, J. J., Hall, T. L., Fowlkes, J. B., O'Donnell, M., & Cain, C. A. (2004). Aberration correction by nonlinear beam-mixing: Generation of a pseudo point sound source. Proceedings - IEEE Ultrasonics Symposium, 1, 130-133.
Seo, Jongbum ; Choi, J. J. ; Hall, T. L. ; Fowlkes, J. B. ; O'Donnell, M. ; Cain, C. A. / Aberration correction by nonlinear beam-mixing : Generation of a pseudo point sound source. In: Proceedings - IEEE Ultrasonics Symposium. 2004 ; Vol. 1. pp. 130-133.
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Seo, J, Choi, JJ, Hall, TL, Fowlkes, JB, O'Donnell, M & Cain, CA 2004, 'Aberration correction by nonlinear beam-mixing: Generation of a pseudo point sound source', Proceedings - IEEE Ultrasonics Symposium, vol. 1, pp. 130-133.

Aberration correction by nonlinear beam-mixing : Generation of a pseudo point sound source. / Seo, Jongbum; Choi, J. J.; Hall, T. L.; Fowlkes, J. B.; O'Donnell, M.; Cain, C. A.

In: Proceedings - IEEE Ultrasonics Symposium, Vol. 1, 01.12.2004, p. 130-133.

Research output: Contribution to journalConference article

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AU - Choi, J. J.

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AU - O'Donnell, M.

AU - Cain, C. A.

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