Ablation Volume Measurement After Percutaneous Cryoablation Using a Two-cryo-probe Technique for Small Hepatocellular Carcinomas

Dong Kyu Kim, Joon Ho Kwon, Jong Yun Won, Kichang Han, Gyoung Min Kim, ManDeuk Kim, Do Yun Lee

Research output: Contribution to journalArticle

Abstract

Purpose: To calculate the ablation volume of percutaneous cryoablation (PCA) with a two-cryo-probe technique for small hepatocellular carcinomas (HCCs) and to assess risk factors for local tumor recurrence (LTR). Materials and Methods: Between January 2013 and June 2017, 96 patients (mean age, 60.7 years; range, 37–83 years) with 106 small HCCs were retrospectively analyzed. The ablation volume, technical success, LTR rates, and complications were evaluated. Ablation volume was measured after the first freezing and immediately after completing PCA twice via computed tomography imaging. Prognostic factors associated with LTR were analyzed. Results: Technical success was achieved in all patients. The mean final ablation volume was 19.1 ± 4.8 cm 3 , which was significantly higher than the first freezing ablation volume (14.7 ± 4.3 cm 3 , p < 0.001). During the median follow-up period of 16.7 months (range, 5–52 months), LTR-free survival rates based on Kaplan–Meier analyses at 6 months, 1 year, and 2 years were 87.7%, 84.0%, and 80.2%, respectively. Only one major complication of post-procedural arterial bleeding occurred. A final ablation volume/tumor volume < 10 was a significant risk factor for LTR (p = 0.044). Conclusions: A ratio of final ablation volume to tumor volume < 10 was a significant prognostic factor for LTR. Therefore, the measurement and prediction of the final ablation volume are important to reduce LTR.

Original languageEnglish
Pages (from-to)220-229
Number of pages10
JournalCardiovascular and interventional radiology
Volume42
Issue number2
DOIs
Publication statusPublished - 2019 Feb 15

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Cryosurgery
Hepatocellular Carcinoma
Recurrence
Neoplasms
Tumor Burden
Freezing
Survival Rate
Tomography
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Dong Kyu ; Kwon, Joon Ho ; Won, Jong Yun ; Han, Kichang ; Kim, Gyoung Min ; Kim, ManDeuk ; Lee, Do Yun. / Ablation Volume Measurement After Percutaneous Cryoablation Using a Two-cryo-probe Technique for Small Hepatocellular Carcinomas. In: Cardiovascular and interventional radiology. 2019 ; Vol. 42, No. 2. pp. 220-229.
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abstract = "Purpose: To calculate the ablation volume of percutaneous cryoablation (PCA) with a two-cryo-probe technique for small hepatocellular carcinomas (HCCs) and to assess risk factors for local tumor recurrence (LTR). Materials and Methods: Between January 2013 and June 2017, 96 patients (mean age, 60.7 years; range, 37–83 years) with 106 small HCCs were retrospectively analyzed. The ablation volume, technical success, LTR rates, and complications were evaluated. Ablation volume was measured after the first freezing and immediately after completing PCA twice via computed tomography imaging. Prognostic factors associated with LTR were analyzed. Results: Technical success was achieved in all patients. The mean final ablation volume was 19.1 ± 4.8 cm 3 , which was significantly higher than the first freezing ablation volume (14.7 ± 4.3 cm 3 , p < 0.001). During the median follow-up period of 16.7 months (range, 5–52 months), LTR-free survival rates based on Kaplan–Meier analyses at 6 months, 1 year, and 2 years were 87.7{\%}, 84.0{\%}, and 80.2{\%}, respectively. Only one major complication of post-procedural arterial bleeding occurred. A final ablation volume/tumor volume < 10 was a significant risk factor for LTR (p = 0.044). Conclusions: A ratio of final ablation volume to tumor volume < 10 was a significant prognostic factor for LTR. Therefore, the measurement and prediction of the final ablation volume are important to reduce LTR.",
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Ablation Volume Measurement After Percutaneous Cryoablation Using a Two-cryo-probe Technique for Small Hepatocellular Carcinomas. / Kim, Dong Kyu; Kwon, Joon Ho; Won, Jong Yun; Han, Kichang; Kim, Gyoung Min; Kim, ManDeuk; Lee, Do Yun.

In: Cardiovascular and interventional radiology, Vol. 42, No. 2, 15.02.2019, p. 220-229.

Research output: Contribution to journalArticle

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AU - Kim, Gyoung Min

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N2 - Purpose: To calculate the ablation volume of percutaneous cryoablation (PCA) with a two-cryo-probe technique for small hepatocellular carcinomas (HCCs) and to assess risk factors for local tumor recurrence (LTR). Materials and Methods: Between January 2013 and June 2017, 96 patients (mean age, 60.7 years; range, 37–83 years) with 106 small HCCs were retrospectively analyzed. The ablation volume, technical success, LTR rates, and complications were evaluated. Ablation volume was measured after the first freezing and immediately after completing PCA twice via computed tomography imaging. Prognostic factors associated with LTR were analyzed. Results: Technical success was achieved in all patients. The mean final ablation volume was 19.1 ± 4.8 cm 3 , which was significantly higher than the first freezing ablation volume (14.7 ± 4.3 cm 3 , p < 0.001). During the median follow-up period of 16.7 months (range, 5–52 months), LTR-free survival rates based on Kaplan–Meier analyses at 6 months, 1 year, and 2 years were 87.7%, 84.0%, and 80.2%, respectively. Only one major complication of post-procedural arterial bleeding occurred. A final ablation volume/tumor volume < 10 was a significant risk factor for LTR (p = 0.044). Conclusions: A ratio of final ablation volume to tumor volume < 10 was a significant prognostic factor for LTR. Therefore, the measurement and prediction of the final ablation volume are important to reduce LTR.

AB - Purpose: To calculate the ablation volume of percutaneous cryoablation (PCA) with a two-cryo-probe technique for small hepatocellular carcinomas (HCCs) and to assess risk factors for local tumor recurrence (LTR). Materials and Methods: Between January 2013 and June 2017, 96 patients (mean age, 60.7 years; range, 37–83 years) with 106 small HCCs were retrospectively analyzed. The ablation volume, technical success, LTR rates, and complications were evaluated. Ablation volume was measured after the first freezing and immediately after completing PCA twice via computed tomography imaging. Prognostic factors associated with LTR were analyzed. Results: Technical success was achieved in all patients. The mean final ablation volume was 19.1 ± 4.8 cm 3 , which was significantly higher than the first freezing ablation volume (14.7 ± 4.3 cm 3 , p < 0.001). During the median follow-up period of 16.7 months (range, 5–52 months), LTR-free survival rates based on Kaplan–Meier analyses at 6 months, 1 year, and 2 years were 87.7%, 84.0%, and 80.2%, respectively. Only one major complication of post-procedural arterial bleeding occurred. A final ablation volume/tumor volume < 10 was a significant risk factor for LTR (p = 0.044). Conclusions: A ratio of final ablation volume to tumor volume < 10 was a significant prognostic factor for LTR. Therefore, the measurement and prediction of the final ablation volume are important to reduce LTR.

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