Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder

Jun Sang Sunwoo, Kwang Su Cha, Jung Ick Byun, Tae Joon Kim, Jin Sun Jun, Jung Ah Lim, Soon Tae Lee, Keun Hwa Jung, Kyung Il Park, Kon Chu, Han Joon Kim, Manho Kim, Sang Kun Lee, Kyunghwan Kim, Carlos H. Schenck, Ki Young Jung

Research output: Contribution to journalArticle

Abstract

Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6%) and 10 controls (mean age, 62.3 years; men, 70%) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.

Original languageEnglish
JournalSleep
Volume42
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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REM Sleep Behavior Disorder
REM Sleep
Sleep
Electroencephalography
Parietal Lobe
Behavior Control
Motor Cortex

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Sunwoo, J. S., Cha, K. S., Byun, J. I., Kim, T. J., Jun, J. S., Lim, J. A., ... Jung, K. Y. (2019). Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder. Sleep, 42(2). https://doi.org/10.1093/sleep/zsy227
Sunwoo, Jun Sang ; Cha, Kwang Su ; Byun, Jung Ick ; Kim, Tae Joon ; Jun, Jin Sun ; Lim, Jung Ah ; Lee, Soon Tae ; Jung, Keun Hwa ; Park, Kyung Il ; Chu, Kon ; Kim, Han Joon ; Kim, Manho ; Lee, Sang Kun ; Kim, Kyunghwan ; Schenck, Carlos H. ; Jung, Ki Young. / Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder. In: Sleep. 2019 ; Vol. 42, No. 2.
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title = "Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder",
abstract = "Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6{\%}) and 10 controls (mean age, 62.3 years; men, 70{\%}) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.",
author = "Sunwoo, {Jun Sang} and Cha, {Kwang Su} and Byun, {Jung Ick} and Kim, {Tae Joon} and Jun, {Jin Sun} and Lim, {Jung Ah} and Lee, {Soon Tae} and Jung, {Keun Hwa} and Park, {Kyung Il} and Kon Chu and Kim, {Han Joon} and Manho Kim and Lee, {Sang Kun} and Kyunghwan Kim and Schenck, {Carlos H.} and Jung, {Ki Young}",
year = "2019",
month = "2",
day = "1",
doi = "10.1093/sleep/zsy227",
language = "English",
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journal = "Sleep",
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Sunwoo, JS, Cha, KS, Byun, JI, Kim, TJ, Jun, JS, Lim, JA, Lee, ST, Jung, KH, Park, KI, Chu, K, Kim, HJ, Kim, M, Lee, SK, Kim, K, Schenck, CH & Jung, KY 2019, 'Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder', Sleep, vol. 42, no. 2. https://doi.org/10.1093/sleep/zsy227

Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder. / Sunwoo, Jun Sang; Cha, Kwang Su; Byun, Jung Ick; Kim, Tae Joon; Jun, Jin Sun; Lim, Jung Ah; Lee, Soon Tae; Jung, Keun Hwa; Park, Kyung Il; Chu, Kon; Kim, Han Joon; Kim, Manho; Lee, Sang Kun; Kim, Kyunghwan; Schenck, Carlos H.; Jung, Ki Young.

In: Sleep, Vol. 42, No. 2, 01.02.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder

AU - Sunwoo, Jun Sang

AU - Cha, Kwang Su

AU - Byun, Jung Ick

AU - Kim, Tae Joon

AU - Jun, Jin Sun

AU - Lim, Jung Ah

AU - Lee, Soon Tae

AU - Jung, Keun Hwa

AU - Park, Kyung Il

AU - Chu, Kon

AU - Kim, Han Joon

AU - Kim, Manho

AU - Lee, Sang Kun

AU - Kim, Kyunghwan

AU - Schenck, Carlos H.

AU - Jung, Ki Young

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6%) and 10 controls (mean age, 62.3 years; men, 70%) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.

AB - Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6%) and 10 controls (mean age, 62.3 years; men, 70%) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.

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