Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia

Seon Koo Lee, Ji Won Chun, Jung Suk Lee, Hae Jeong Park, Young Chul Jung, Jeong Ho Seok, Jae-Jin Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we investigated the neural correlates of emotional salience attribution in patients with schizophrenia when affective asymmetry was processed. Fifteen patients with schizophrenia and 14 healthy controls were scanned using functional magnetic resonance imaging (fMRI) while performing an emotion judgment task in which two pictures were juxtaposed. The task consisted of responding to affective asymmetry condition (ambivalent and neutral) and affective symmetry conditions (positive and negative), and group comparisons were performed for each condition. Significantly higher activity in the medial prefrontal cortex and inferior frontal gyrus was observed for the ambivalent condition than for the other conditions in controls, but not in patients. Compared with controls, patients showed decreased activities in the dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, insula, and putamen for the ambivalent condition, but no changes were observed for the neutral condition. Multiple prefrontal hypoactivities during salience attribution of negativity bias in schizophrenia may underlie deficits in the integrative processing of emotional information. Regional abnormalities in the salience network may be the basis of defective emotional salience attribution in schizophrenia, which is likely involved in symptom formation and social dysfunction.

Original languageEnglish
Article numbere90792
JournalPLoS ONE
Volume9
Issue number3
DOIs
Publication statusPublished - 2014 Mar 11

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Schizophrenia
Prefrontal Cortex
Processing
Putamen
Gyrus Cinguli
emotions
Automatic Data Processing
magnetic resonance imaging
signs and symptoms (animals and humans)
cortex
Emotions
Magnetic Resonance Imaging
schizophrenia
prefrontal cortex

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Seon Koo ; Chun, Ji Won ; Lee, Jung Suk ; Park, Hae Jeong ; Jung, Young Chul ; Seok, Jeong Ho ; Kim, Jae-Jin. / Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia. In: PLoS ONE. 2014 ; Vol. 9, No. 3.
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Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia. / Lee, Seon Koo; Chun, Ji Won; Lee, Jung Suk; Park, Hae Jeong; Jung, Young Chul; Seok, Jeong Ho; Kim, Jae-Jin.

In: PLoS ONE, Vol. 9, No. 3, e90792, 11.03.2014.

Research output: Contribution to journalArticle

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