Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Seung Hoon Yang; Jiyoon Kim; Michael Jisoo Lee; Youngsoo Kim

doi:10.1038/srep15703

Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Seung Hoon Yang, Jiyoon Kim, Michael Jisoo Lee, Youngsoo Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APP_swe, PS1_M146V and Tau_P301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

Original language	English
Article number	15703
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep15703
Publication status	Published - 2015 Oct 27

Bibliographical note

Funding Information:
This work was funded by Korea Health Industry Development Institute (KHIDI, HI14C3319) and KIST Institutional Programs (2E25732, 2E25240 and 2E25473). The authors thank Dr. Soo Min Cho (Korea Institute of Science and Technology) and Hyunjin Vincent Kim (Korea Institute of Science and Technology) for technical assistance of plasma and CSF preparation; Yakdol Cho (Korea Institute of Science and Technology) for animal maintenance and preparation; Prof. Joo-Won Park (Ewha Womans University), Prof. Woo-Jae Park (Gachon University) and So-Yeon Kim (Ewha Womans University) for technical assistance of FACS analysis and immunostaining. The authors appreciate Dr. Hye Yun Kim (Korea Institute of Science and Technology) for scientific advices.

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title = "Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model",

abstract = "The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.",

author = "Yang, {Seung Hoon} and Jiyoon Kim and Lee, {Michael Jisoo} and Youngsoo Kim",

note = "Funding Information: This work was funded by Korea Health Industry Development Institute (KHIDI, HI14C3319) and KIST Institutional Programs (2E25732, 2E25240 and 2E25473). The authors thank Dr. Soo Min Cho (Korea Institute of Science and Technology) and Hyunjin Vincent Kim (Korea Institute of Science and Technology) for technical assistance of plasma and CSF preparation; Yakdol Cho (Korea Institute of Science and Technology) for animal maintenance and preparation; Prof. Joo-Won Park (Ewha Womans University), Prof. Woo-Jae Park (Gachon University) and So-Yeon Kim (Ewha Womans University) for technical assistance of FACS analysis and immunostaining. The authors appreciate Dr. Hye Yun Kim (Korea Institute of Science and Technology) for scientific advices.",

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N1 - Funding Information: This work was funded by Korea Health Industry Development Institute (KHIDI, HI14C3319) and KIST Institutional Programs (2E25732, 2E25240 and 2E25473). The authors thank Dr. Soo Min Cho (Korea Institute of Science and Technology) and Hyunjin Vincent Kim (Korea Institute of Science and Technology) for technical assistance of plasma and CSF preparation; Yakdol Cho (Korea Institute of Science and Technology) for animal maintenance and preparation; Prof. Joo-Won Park (Ewha Womans University), Prof. Woo-Jae Park (Gachon University) and So-Yeon Kim (Ewha Womans University) for technical assistance of FACS analysis and immunostaining. The authors appreciate Dr. Hye Yun Kim (Korea Institute of Science and Technology) for scientific advices.

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N2 - The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

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Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Abstract

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