Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Seung Hoon Yang, Jiyoon Kim, Michael Jisoo Lee, Youngsoo Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

Original languageEnglish
Article number15703
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Oct 27

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model'. Together they form a unique fingerprint.

  • Cite this