Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle

Ngoc Hoan Le, Chu Sook Kim, Thai Hien Tu, Byung Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha, Rina Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We previously reported that 4-1BB, a member of the tumor necrosis factor receptor superfamily, participated in obesity-induced skeletal muscle inflammation. Here, we show that the absence of 4-1BB in obese mice fed a high-fat diet led to a decrease in expression of atrophic factors (MuRF1 and Atrogin-1) with suppression of NF-κB activity, and that this was accompanied by increases in mitochondrial oxidative metabolic genes/proteins (e.g., PGC-1α, CPT1β, etc.) expression and oxidative muscle fibers marker genes/proteins in the skeletal muscle. These findings suggest that 4-1BB-mediated inflammatory signaling could be a potential target for combating obesity-related muscle atrophy and metabolic derangement in skeletal muscle.

Original languageEnglish
Article number9
JournalJournal of Inflammation (United Kingdom)
Volume14
Issue number1
DOIs
Publication statusPublished - 2017 May 11

Bibliographical note

Funding Information:
This work was supported by the Science Research Center program (Center for Food & Nutritional Genomics Research, Grant 2015R1A5A6001906) of the NRF of Korea funded by the MEST, and by a grant from the Korea Food Research Institute (KFRI E0160500-02).

Publisher Copyright:
© 2017 The Author(s).

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

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