Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We previously reported that 4-1BB, a member of the tumor necrosis factor receptor superfamily, participated in obesity-induced skeletal muscle inflammation. Here, we show that the absence of 4-1BB in obese mice fed a high-fat diet led to a decrease in expression of atrophic factors (MuRF1 and Atrogin-1) with suppression of NF-κB activity, and that this was accompanied by increases in mitochondrial oxidative metabolic genes/proteins (e.g., PGC-1α, CPT1β, etc.) expression and oxidative muscle fibers marker genes/proteins in the skeletal muscle. These findings suggest that 4-1BB-mediated inflammatory signaling could be a potential target for combating obesity-related muscle atrophy and metabolic derangement in skeletal muscle.
Bibliographical noteFunding Information:
This work was supported by the Science Research Center program (Center for Food & Nutritional Genomics Research, Grant 2015R1A5A6001906) of the NRF of Korea funded by the MEST, and by a grant from the Korea Food Research Institute (KFRI E0160500-02).
© 2017 The Author(s).
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Cell Biology