Purpose: The purpose of our study was to evaluate the under estimation rate of atypical ductal hyperplasia (ADH) on vacuum- assisted breast biopsy (VABB), and to examine the correlation between residual microcalcifications and the underestimation rate of ADH. Methods: A retrospective study was performed on 27 women (mean age, 49.2±9.2 years) who underwent addi tional excision for ADH via VABB for microcalcifications ob served by using mammography. The mammographic findings, histopathologic diagnosis of all VABB and surgical specimens, and association of malignancy with residual microcalcifications were evaluated. The underestimation rate of ADH was also cal culated. Results: Of the 27 women with microcalcifications, nine were upgraded to ductal carcinoma in situ (DCIS); thus, the un derestimation rate was 33.3% (9/27). There was no difference in age (p=0.40) and extent of microcalcifications (p=0.10) when comparing benign and malignant cases. Six of 17 patients (35.3%) with remaining calcifications after VABB were upgraded to DCIS, and three of 10 patients (30%) with no residual calcifi cations after VABB were upgraded (p=1.00). Conclusion: The underestimation rate of ADH on VABB was 33.3%. Furthermore, 30% of patients with no remaining calcifications were upgraded to DCIS. Therefore, we conclude that all ADH cases diagnosed via VABB should be excised regardless of the presence of resid ual microcalcifications.
All Science Journal Classification (ASJC) codes
- Cancer Research