Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus

An association with clinical significance

Hee Jung Yoon, JunYong Choi, Kyungwon Lee, DongEun Yong, June Myung Kim, Young Goo Song

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Virulent gene expression in Staphylococcus aureus is controlled by regulators such as the accessory gene regulator (agr). Strains can be divided into four major agr groups (agr I-IV) on the basis of agrD and agrC polymorphisms. The purpose of this study was to define the proportion of agr I, II, and III polymorphisms and to compare the clinical characteristics between group I and non-group I polymorphisms of methicillin-resistant Staphylococcus aureus (MRSA) strains in a Korean tertiary care teaching hospital. Materials and Methods: A total of 158 clinical isolates were evaluated by RFLPs (restriction fragment length polymorphisms). Results: The mean age of the patients was 50.2 ± 21.9 years old. There were 74 (49.3%), 66 (44.0%), 10 (6.7%), 7 (4.4%), and 1 (0.6%) strains in agr group I, II, III, I + II, and I + III polymorphisms, respectively. Only ear infections were a statistically significant clinical parameter according to univariate (p= 0.001) and multivariate analysis (OR, 4.721 (1.273-17.508), p= 0.020). Conclusion: This study suggests that agr group I is the most prevalent in Korea, and ear infections are correlated with the group I polymorphism, which is a different clinical trend from western countries. It can also be inferred that community-acquired MRSA correlates with agr group I.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalYonsei medical journal
Volume48
Issue number2
DOIs
Publication statusPublished - 2007 Apr 1

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Regulator Genes
Methicillin-Resistant Staphylococcus aureus
Ear
Tertiary Healthcare
Korea
Infection
Teaching Hospitals
Restriction Fragment Length Polymorphisms
Staphylococcus aureus
Multivariate Analysis
Gene Expression

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus: An association with clinical significance",
abstract = "Purpose: Virulent gene expression in Staphylococcus aureus is controlled by regulators such as the accessory gene regulator (agr). Strains can be divided into four major agr groups (agr I-IV) on the basis of agrD and agrC polymorphisms. The purpose of this study was to define the proportion of agr I, II, and III polymorphisms and to compare the clinical characteristics between group I and non-group I polymorphisms of methicillin-resistant Staphylococcus aureus (MRSA) strains in a Korean tertiary care teaching hospital. Materials and Methods: A total of 158 clinical isolates were evaluated by RFLPs (restriction fragment length polymorphisms). Results: The mean age of the patients was 50.2 ± 21.9 years old. There were 74 (49.3{\%}), 66 (44.0{\%}), 10 (6.7{\%}), 7 (4.4{\%}), and 1 (0.6{\%}) strains in agr group I, II, III, I + II, and I + III polymorphisms, respectively. Only ear infections were a statistically significant clinical parameter according to univariate (p= 0.001) and multivariate analysis (OR, 4.721 (1.273-17.508), p= 0.020). Conclusion: This study suggests that agr group I is the most prevalent in Korea, and ear infections are correlated with the group I polymorphism, which is a different clinical trend from western countries. It can also be inferred that community-acquired MRSA correlates with agr group I.",
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Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus : An association with clinical significance. / Yoon, Hee Jung; Choi, JunYong; Lee, Kyungwon; Yong, DongEun; Kim, June Myung; Song, Young Goo.

In: Yonsei medical journal, Vol. 48, No. 2, 01.04.2007, p. 176-183.

Research output: Contribution to journalArticle

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