Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Behçet's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin, EliATM Calprotectin, and RIDASCREEN® Calprotectin). Results: The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 mg/g); 92% and 89%, respectively, for EliATM (cutoff, 50 mg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue® Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.
Bibliographical noteFunding Information:
This study was supported in part by the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and funded by the Ministry of Health and Welfare, Republic of Korea (grant numbers: A111428, HI13C1345, and HI12C0130). It was also supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A1A1008096).
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