Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease

Hui Won Jang, Hyonsuk Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, JaeHee Cheon

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Abstract

Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Behçet's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin, EliATM Calprotectin, and RIDASCREEN® Calprotectin). Results: The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 mg/g); 92% and 89%, respectively, for EliATM (cutoff, 50 mg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue® Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalIntestinal Research
Volume14
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

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Leukocyte L1 Antigen Complex
Inflammatory Bowel Diseases
Colitis
Crohn Disease
Irritable Bowel Syndrome
Ulcerative Colitis
Intestinal Diseases
Nonparametric Statistics
Early Diagnosis
Tuberculosis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Jang, Hui Won ; Kim, Hyonsuk ; Park, Soo Jung ; Hong, Sung Pil ; Kim, Tae Il ; Kim, Won Ho ; Cheon, JaeHee. / Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease. In: Intestinal Research. 2016 ; Vol. 14, No. 4. pp. 305-313.
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abstract = "Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Beh{\cc}et's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue{\circledR} Calprotectin, EliATM Calprotectin, and RIDASCREEN{\circledR} Calprotectin). Results: The overall accuracy for differentiating IBD from IBS or other colitis was 94{\%} and 91{\%}, respectively, for Quantum Blue{\circledR} (cutoff, 50 mg/g); 92{\%} and 89{\%}, respectively, for EliATM (cutoff, 50 mg/g); and 82{\%} and 76{\%}, respectively, for RIDASCREEN{\circledR} (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue{\circledR} Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.",
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Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease. / Jang, Hui Won; Kim, Hyonsuk; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, JaeHee.

In: Intestinal Research, Vol. 14, No. 4, 01.01.2016, p. 305-313.

Research output: Contribution to journalArticle

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N2 - Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Behçet's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin, EliATM Calprotectin, and RIDASCREEN® Calprotectin). Results: The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 mg/g); 92% and 89%, respectively, for EliATM (cutoff, 50 mg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue® Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.

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