Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease

Hui Won Jang, Hyun Sook Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon

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Abstract

Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Behçet's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin, EliATM Calprotectin, and RIDASCREEN® Calprotectin). Results: The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 mg/g); 92% and 89%, respectively, for EliATM (cutoff, 50 mg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue® Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalIntestinal Research
Volume14
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

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