ACE DD genotype is unfavorable to korean short-term muscle power athletes

C. H. Kim, J. Y. Cho, J. Y. Jeon, Y. G. Koh, Y. M. Kim, H. J. Kim, M. Park, H. S. Um, C. Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The purpose of this study was to test the hypothesis that the ACE DD genotype is unfavorably associated with the ultimate power-oriented performance. To test the hypothesis we recruited a total of 848 subjects including 55 international level power-oriented athletes (High-performance), 100 national level power-oriented athletes (Mid-performance) and 693 healthy controls (Control) in Korea. Then the distributions of ACE polymorphism throughout these groups were analyzed. As a result, there was a gradual decrease of frequencies of the DD genotype with advancing levels of performance (Control vs. Mid-performance vs. High-performance=17.2% vs. 10.0% vs. 5.5%, p=0.002). Also, the frequencies of D allele decreased gradually with advancing levels of performance (Control vs. Mid-performance vs. High-performance=42.6% vs. 35.0% vs. 30.9%, p<0.01). Therefore, power-oriented athletes at the top level had a markedly diminished frequency of the DD genotype and the D allele. This finding gave 3.83 times lower probability of success in power-oriented sports for individuals with the DD genotype than those with the II+ID genotype. In conclusion, these results indicate that Korean power-oriented athletes with a lower frequency of the DD genotype had a lower probability of success in power-oriented sports.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalInternational Journal of Sports Medicine
Volume31
Issue number1
DOIs
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Kim, C. H., Cho, J. Y., Jeon, J. Y., Koh, Y. G., Kim, Y. M., Kim, H. J., Park, M., Um, H. S., & Kim, C. (2010). ACE DD genotype is unfavorable to korean short-term muscle power athletes. International Journal of Sports Medicine, 31(1), 65-71. https://doi.org/10.1055/s-0029-1239523