ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: Effect of ACE gene DD on the progression of diabetic nephropathy

Sung Kyu Ha, Hyeong Cheon Park, Hong Su Park, Byung Seung Kang, Tae Hee Lee, Hak Jin Hwang, Seung Jung Kim, Do Hun Kim, Shin-Wook Kang, Kyu Hun Choi, Ho Yung Lee, Dae Suk Han

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Abstract

Background: Pathophysiological causes of the development and progression of diabetic nephropathy are not well known, but the angiotensin-converting enzyme (ACE) gene polymorphism has been proposed to be involved in its development and progression. Methods: The impact of insertion/deletion (I/D) genotypes on the progression of diabetic nephropathy in 239 Korean patients with type 2 diabetes (99 patients with stable renal function, group 1; 140 patients with declining renal function, group 2) was investigated by retrospective review of clinical data. Results: The frequency of the DD genotype was significantly greater in group 2 compared with group I (30.7% versus 9.1%; P < 0.05). There were no significant differences in age, blood pressure, hemoglobin A1c levels, or lipid profiles among ACE genotype groups. However, the prevalence of retinopathy was significantly greater in patients with the DD genotype (DD, ID, and II, 90.4%, 71.2%, and 70.6%, respectively; P < 0.05). Patients with the DD genotype reached the end point (serum creatinine > 2.0 mg/dL [176.8/μmol/L]) faster than those with the other genotypes (DD, 11.38 ± 4.08 years; ID, 13.85 ± 4.04 years; II, 14.04 ± 4.06 years, respectively; P < 0.05) and took significantly less time to reach dialysis therapy (DD, 13.10 ± 4.45 years; ID, 16.21 ± 4.74 years; II, 15.13 ± 4.09 years, respectively; P < 0.05). In multiple logistic regression analysis, systolic blood pressure and DD genotype showed significant correlations with the progression of diabetic nephropathy. In patients with the DD genotype, the odds ratio was 3.881 (95% confidence interval, 1.564 ∼ 9.628; P = 0.003) compared with those with the II genotype. Conclusion: It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy.

Original languageEnglish
Pages (from-to)943-949
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume41
Issue number5
DOIs
Publication statusPublished - 2003 May 1

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Diabetic Nephropathies
Peptidyl-Dipeptidase A
Genotype
Genes
Blood Pressure
Kidney
Type 2 Diabetes Mellitus
Dialysis
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Ha, Sung Kyu ; Park, Hyeong Cheon ; Park, Hong Su ; Kang, Byung Seung ; Lee, Tae Hee ; Hwang, Hak Jin ; Kim, Seung Jung ; Kim, Do Hun ; Kang, Shin-Wook ; Choi, Kyu Hun ; Lee, Ho Yung ; Han, Dae Suk. / ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients : Effect of ACE gene DD on the progression of diabetic nephropathy. In: American Journal of Kidney Diseases. 2003 ; Vol. 41, No. 5. pp. 943-949.
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abstract = "Background: Pathophysiological causes of the development and progression of diabetic nephropathy are not well known, but the angiotensin-converting enzyme (ACE) gene polymorphism has been proposed to be involved in its development and progression. Methods: The impact of insertion/deletion (I/D) genotypes on the progression of diabetic nephropathy in 239 Korean patients with type 2 diabetes (99 patients with stable renal function, group 1; 140 patients with declining renal function, group 2) was investigated by retrospective review of clinical data. Results: The frequency of the DD genotype was significantly greater in group 2 compared with group I (30.7{\%} versus 9.1{\%}; P < 0.05). There were no significant differences in age, blood pressure, hemoglobin A1c levels, or lipid profiles among ACE genotype groups. However, the prevalence of retinopathy was significantly greater in patients with the DD genotype (DD, ID, and II, 90.4{\%}, 71.2{\%}, and 70.6{\%}, respectively; P < 0.05). Patients with the DD genotype reached the end point (serum creatinine > 2.0 mg/dL [176.8/μmol/L]) faster than those with the other genotypes (DD, 11.38 ± 4.08 years; ID, 13.85 ± 4.04 years; II, 14.04 ± 4.06 years, respectively; P < 0.05) and took significantly less time to reach dialysis therapy (DD, 13.10 ± 4.45 years; ID, 16.21 ± 4.74 years; II, 15.13 ± 4.09 years, respectively; P < 0.05). In multiple logistic regression analysis, systolic blood pressure and DD genotype showed significant correlations with the progression of diabetic nephropathy. In patients with the DD genotype, the odds ratio was 3.881 (95{\%} confidence interval, 1.564 ∼ 9.628; P = 0.003) compared with those with the II genotype. Conclusion: It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy.",
author = "Ha, {Sung Kyu} and Park, {Hyeong Cheon} and Park, {Hong Su} and Kang, {Byung Seung} and Lee, {Tae Hee} and Hwang, {Hak Jin} and Kim, {Seung Jung} and Kim, {Do Hun} and Shin-Wook Kang and Choi, {Kyu Hun} and Lee, {Ho Yung} and Han, {Dae Suk}",
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ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients : Effect of ACE gene DD on the progression of diabetic nephropathy. / Ha, Sung Kyu; Park, Hyeong Cheon; Park, Hong Su; Kang, Byung Seung; Lee, Tae Hee; Hwang, Hak Jin; Kim, Seung Jung; Kim, Do Hun; Kang, Shin-Wook; Choi, Kyu Hun; Lee, Ho Yung; Han, Dae Suk.

In: American Journal of Kidney Diseases, Vol. 41, No. 5, 01.05.2003, p. 943-949.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients

T2 - Effect of ACE gene DD on the progression of diabetic nephropathy

AU - Ha, Sung Kyu

AU - Park, Hyeong Cheon

AU - Park, Hong Su

AU - Kang, Byung Seung

AU - Lee, Tae Hee

AU - Hwang, Hak Jin

AU - Kim, Seung Jung

AU - Kim, Do Hun

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

AU - Lee, Ho Yung

AU - Han, Dae Suk

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Pathophysiological causes of the development and progression of diabetic nephropathy are not well known, but the angiotensin-converting enzyme (ACE) gene polymorphism has been proposed to be involved in its development and progression. Methods: The impact of insertion/deletion (I/D) genotypes on the progression of diabetic nephropathy in 239 Korean patients with type 2 diabetes (99 patients with stable renal function, group 1; 140 patients with declining renal function, group 2) was investigated by retrospective review of clinical data. Results: The frequency of the DD genotype was significantly greater in group 2 compared with group I (30.7% versus 9.1%; P < 0.05). There were no significant differences in age, blood pressure, hemoglobin A1c levels, or lipid profiles among ACE genotype groups. However, the prevalence of retinopathy was significantly greater in patients with the DD genotype (DD, ID, and II, 90.4%, 71.2%, and 70.6%, respectively; P < 0.05). Patients with the DD genotype reached the end point (serum creatinine > 2.0 mg/dL [176.8/μmol/L]) faster than those with the other genotypes (DD, 11.38 ± 4.08 years; ID, 13.85 ± 4.04 years; II, 14.04 ± 4.06 years, respectively; P < 0.05) and took significantly less time to reach dialysis therapy (DD, 13.10 ± 4.45 years; ID, 16.21 ± 4.74 years; II, 15.13 ± 4.09 years, respectively; P < 0.05). In multiple logistic regression analysis, systolic blood pressure and DD genotype showed significant correlations with the progression of diabetic nephropathy. In patients with the DD genotype, the odds ratio was 3.881 (95% confidence interval, 1.564 ∼ 9.628; P = 0.003) compared with those with the II genotype. Conclusion: It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy.

AB - Background: Pathophysiological causes of the development and progression of diabetic nephropathy are not well known, but the angiotensin-converting enzyme (ACE) gene polymorphism has been proposed to be involved in its development and progression. Methods: The impact of insertion/deletion (I/D) genotypes on the progression of diabetic nephropathy in 239 Korean patients with type 2 diabetes (99 patients with stable renal function, group 1; 140 patients with declining renal function, group 2) was investigated by retrospective review of clinical data. Results: The frequency of the DD genotype was significantly greater in group 2 compared with group I (30.7% versus 9.1%; P < 0.05). There were no significant differences in age, blood pressure, hemoglobin A1c levels, or lipid profiles among ACE genotype groups. However, the prevalence of retinopathy was significantly greater in patients with the DD genotype (DD, ID, and II, 90.4%, 71.2%, and 70.6%, respectively; P < 0.05). Patients with the DD genotype reached the end point (serum creatinine > 2.0 mg/dL [176.8/μmol/L]) faster than those with the other genotypes (DD, 11.38 ± 4.08 years; ID, 13.85 ± 4.04 years; II, 14.04 ± 4.06 years, respectively; P < 0.05) and took significantly less time to reach dialysis therapy (DD, 13.10 ± 4.45 years; ID, 16.21 ± 4.74 years; II, 15.13 ± 4.09 years, respectively; P < 0.05). In multiple logistic regression analysis, systolic blood pressure and DD genotype showed significant correlations with the progression of diabetic nephropathy. In patients with the DD genotype, the odds ratio was 3.881 (95% confidence interval, 1.564 ∼ 9.628; P = 0.003) compared with those with the II genotype. Conclusion: It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy.

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