Acetal-Based Functional Epoxide Monomers: Polymerizations and Applications

Jinsu Baek, Minseong Kim, Youngsin Park, Byeong Su Kim

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Protecting group chemistry is essential for various organic transformation and polymerization processes. In particular, conventional anionic ring-opening polymerization (AROP) often requires proper protecting group chemistry because it is typically incompatible with most functional groups due to the highly basic and nucleophilic conditions. In this context, many functional epoxide monomers with proper protecting groups are developed, including the acetal group as a representative example. Since the early introduction of ethoxyethyl glycidyl ether, there is significant development of acetal-based monomers in the polyethers. These monomers are now utilized not only as protecting groups for hydroxyl groups under AROP conditions but also as pH-responsive moieties for biomedical applications, further expanding their utility in the use of functionalized polyethers. Recent progress in this field is outlined from their synthesis, polymerization, and biomedical applications.

Original languageEnglish
JournalMacromolecular Bioscience
Publication statusAccepted/In press - 2021

Bibliographical note

Funding Information:
All authors contributed equally to this work. This work was supported by the National Research Foundation of Korea (NRF‐2021R1A2C3004978 and NRF‐2018R1A5A1025208).

Publisher Copyright:
© 2021 Wiley-VCH GmbH

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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