Achalasia combined with esophageal cancer treated by concurrent chemoradiation therapy

Chul Park Jun, Yongchan Lee, Kyum Kim Sang, Jin Kim Yu, Kwan Shin Sung, SangKil Lee, Kim Hoguen, Bai Kim Choong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Achalasia is a rare neurological deficit of the esophagus that produces an impaired relaxation of the lower esophageal sphincter and decreased motility of the esophageal body. Achalasia is generally accepted to be a pre-malignant disorder, since, particularly in the mega-esophagus, chronic irritation by foods and bacterial overgrowth may contribute to the development of dysplasia and carcinoma. We present a case of a 51-year-old man with achalasia combined with esophageal cancer who has had dysphagia symptoms for more than 20 years. Since there was a clinically high possibility of supraclavicular lymph node metastasis, concurrent chemoradiation therapy was scheduled. After the third cycle of chemoradiation therapy, transthoracic esophageolymphadenectomy was performed. Histopathological examination of the main esophagus specimen revealed no residual carcinoma. And the entire regional lymph node areas were free of carcinoma except for one azygos metastatic lymph node. In summary, achalasia is a predisposing factor for esophageal squamous cell carcinoma. Although surveillance endoscopy in achalasia patients is still controversial, periodic screening for cancer development in long-standing achalasia patients might be advisable.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalGut and Liver
Volume3
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

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Esophageal Achalasia
Esophageal Neoplasms
Esophagus
Lymph Nodes
Carcinoma
Therapeutics
Lower Esophageal Sphincter
Deglutition Disorders
Early Detection of Cancer
Causality
Endoscopy
Neoplasm Metastasis
Food

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology

Cite this

Jun, Chul Park ; Lee, Yongchan ; Sang, Kyum Kim ; Yu, Jin Kim ; Sung, Kwan Shin ; Lee, SangKil ; Hoguen, Kim ; Choong, Bai Kim. / Achalasia combined with esophageal cancer treated by concurrent chemoradiation therapy. In: Gut and Liver. 2009 ; Vol. 3, No. 4. pp. 329-333.
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Achalasia combined with esophageal cancer treated by concurrent chemoradiation therapy. / Jun, Chul Park; Lee, Yongchan; Sang, Kyum Kim; Yu, Jin Kim; Sung, Kwan Shin; Lee, SangKil; Hoguen, Kim; Choong, Bai Kim.

In: Gut and Liver, Vol. 3, No. 4, 01.12.2009, p. 329-333.

Research output: Contribution to journalArticle

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AU - Hoguen, Kim

AU - Choong, Bai Kim

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