Acoustic radiation force impulse measurement in renal transplantation: A prospective, longitudinal study with protocol biopsies

Juhan Lee, Young Taik Oh, Dong Jin Joo, Bo Gyoung Ma, A. Lan Lee, Jae Geun Lee, Seung Hwan Song, Seung Up Kim, Dae Chul Jung, Yong Eun Chung, Yu Seun Kim

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Abstract

Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P<0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r=-0.2426, P=0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR]=1.220, P=0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/ BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.

Original languageEnglish
Pages (from-to)e1590
JournalMedicine (United States)
Volume94
Issue number39
DOIs
Publication statusPublished - 2015 Jan 1

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Acoustics
Kidney Transplantation
Longitudinal Studies
Prospective Studies
Radiation
Kidney
Biopsy
Fibrosis
Atrophy
Transplantation
Body Weight
Weights and Measures
Creatinine
Living Donors
Serum
Allografts
Hemodynamics
Odds Ratio
Transplants
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Juhan ; Taik Oh, Young ; Joo, Dong Jin ; Ma, Bo Gyoung ; Lee, A. Lan ; Lee, Jae Geun ; Song, Seung Hwan ; Kim, Seung Up ; Jung, Dae Chul ; Chung, Yong Eun ; Kim, Yu Seun. / Acoustic radiation force impulse measurement in renal transplantation : A prospective, longitudinal study with protocol biopsies. In: Medicine (United States). 2015 ; Vol. 94, No. 39. pp. e1590.
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abstract = "Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P<0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r=-0.2426, P=0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR]=1.220, P=0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/ BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.",
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Acoustic radiation force impulse measurement in renal transplantation : A prospective, longitudinal study with protocol biopsies. / Lee, Juhan; Taik Oh, Young; Joo, Dong Jin; Ma, Bo Gyoung; Lee, A. Lan; Lee, Jae Geun; Song, Seung Hwan; Kim, Seung Up; Jung, Dae Chul; Chung, Yong Eun; Kim, Yu Seun.

In: Medicine (United States), Vol. 94, No. 39, 01.01.2015, p. e1590.

Research output: Contribution to journalArticle

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T2 - A prospective, longitudinal study with protocol biopsies

AU - Lee, Juhan

AU - Taik Oh, Young

AU - Joo, Dong Jin

AU - Ma, Bo Gyoung

AU - Lee, A. Lan

AU - Lee, Jae Geun

AU - Song, Seung Hwan

AU - Kim, Seung Up

AU - Jung, Dae Chul

AU - Chung, Yong Eun

AU - Kim, Yu Seun

PY - 2015/1/1

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N2 - Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P<0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r=-0.2426, P=0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR]=1.220, P=0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/ BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.

AB - Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P<0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r=-0.2426, P=0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR]=1.220, P=0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/ BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.

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