Acridinium salt based fluorescent and colorimetric chemosensor for the detection of cyanide in water

Young Keun Yang, Jinsung Tae

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

(Diagram presented) A new, selective chemosensor has been developed to detect cyanide in water at micromolar concentrations. The acridinium salt used in this sensor system is prepared in a single step from an acridine orange base. Detection is based on the irreversible, 1:1 stoichiometric, nucleophilic addition of cyanide to the 9-position of the acridinium ion. This process induces a large decrease In fluorescence intensity and a marked color change. The selectivity of the system in aqueous media for CN- over other anions is remarkably high. Also, the sensitivity of both the fluorescence- and colorimetric-based assay is below the 1.9 μM suggested by the World Health Organization (WHO) as the maximum allowable cyanide concentration in drinking water. Thus, the chemodosimeter should be applicable as a practical system for the monitoring of CN- concentrations in aqueous samples.

Original languageEnglish
Pages (from-to)5721-5723
Number of pages3
JournalOrganic Letters
Volume8
Issue number25
DOIs
Publication statusPublished - 2006 Dec 7

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Cyanides
cyanides
Salts
salts
Water
Maximum Allowable Concentration
Fluorescence
water
fluorescence
Acridine Orange
drinking
Drinking Water
health
Anions
Assays
Color
selectivity
diagrams
Health
Ions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "(Diagram presented) A new, selective chemosensor has been developed to detect cyanide in water at micromolar concentrations. The acridinium salt used in this sensor system is prepared in a single step from an acridine orange base. Detection is based on the irreversible, 1:1 stoichiometric, nucleophilic addition of cyanide to the 9-position of the acridinium ion. This process induces a large decrease In fluorescence intensity and a marked color change. The selectivity of the system in aqueous media for CN- over other anions is remarkably high. Also, the sensitivity of both the fluorescence- and colorimetric-based assay is below the 1.9 μM suggested by the World Health Organization (WHO) as the maximum allowable cyanide concentration in drinking water. Thus, the chemodosimeter should be applicable as a practical system for the monitoring of CN- concentrations in aqueous samples.",
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Acridinium salt based fluorescent and colorimetric chemosensor for the detection of cyanide in water. / Yang, Young Keun; Tae, Jinsung.

In: Organic Letters, Vol. 8, No. 25, 07.12.2006, p. 5721-5723.

Research output: Contribution to journalArticle

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AB - (Diagram presented) A new, selective chemosensor has been developed to detect cyanide in water at micromolar concentrations. The acridinium salt used in this sensor system is prepared in a single step from an acridine orange base. Detection is based on the irreversible, 1:1 stoichiometric, nucleophilic addition of cyanide to the 9-position of the acridinium ion. This process induces a large decrease In fluorescence intensity and a marked color change. The selectivity of the system in aqueous media for CN- over other anions is remarkably high. Also, the sensitivity of both the fluorescence- and colorimetric-based assay is below the 1.9 μM suggested by the World Health Organization (WHO) as the maximum allowable cyanide concentration in drinking water. Thus, the chemodosimeter should be applicable as a practical system for the monitoring of CN- concentrations in aqueous samples.

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