Abstract
Recent studies suggest that the gene encoding aldose reductase, the enzyme that converts glucose to sorbitol, may confer susceptibility to microvascular disease. The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy. DNA from 127 Korean patients with type 2 diabetes was typed for an (AC)n dinucleotide repeat polymorphic marker at the 5′-end of the aldose reductase gene using polymerase chain reaction. No significant difference in the frequency of the putative risk allele Z-2 was found in patients of nephropathy and retinopathy groups compared with the uncomplicated group (32.2, 34.1 vs. 25.1%, respectively, P>0.05). Similarly, no difference was found in the frequency of the putative protective allele Z+2 among any of the study groups. In conclusion, the results of the study in Korean type 2 diabetic patients do not support the hypothesis that polymorphism at the 5′ end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular complications.
| Original language | English |
|---|---|
| Pages (from-to) | 151-157 |
| Number of pages | 7 |
| Journal | Diabetes Research and Clinical Practice |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 Jan 22 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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(AC)n polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus. / Park, H. K.; Ahn, C. W.; Lee, G. T.; Kim, S. J.; Song, Y. D.; Lim, S. K.; Kim, K. R.; Huh, K. B.; Lee, H. C.
In: Diabetes Research and Clinical Practice, Vol. 55, No. 2, 22.01.2002, p. 151-157.Research output: Contribution to journal › Article
TY - JOUR
T1 - (AC)n polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus
AU - Park, H. K.
AU - Ahn, C. W.
AU - Lee, G. T.
AU - Kim, S. J.
AU - Song, Y. D.
AU - Lim, S. K.
AU - Kim, K. R.
AU - Huh, K. B.
AU - Lee, H. C.
PY - 2002/1/22
Y1 - 2002/1/22
N2 - Recent studies suggest that the gene encoding aldose reductase, the enzyme that converts glucose to sorbitol, may confer susceptibility to microvascular disease. The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy. DNA from 127 Korean patients with type 2 diabetes was typed for an (AC)n dinucleotide repeat polymorphic marker at the 5′-end of the aldose reductase gene using polymerase chain reaction. No significant difference in the frequency of the putative risk allele Z-2 was found in patients of nephropathy and retinopathy groups compared with the uncomplicated group (32.2, 34.1 vs. 25.1%, respectively, P>0.05). Similarly, no difference was found in the frequency of the putative protective allele Z+2 among any of the study groups. In conclusion, the results of the study in Korean type 2 diabetic patients do not support the hypothesis that polymorphism at the 5′ end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular complications.
AB - Recent studies suggest that the gene encoding aldose reductase, the enzyme that converts glucose to sorbitol, may confer susceptibility to microvascular disease. The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy. DNA from 127 Korean patients with type 2 diabetes was typed for an (AC)n dinucleotide repeat polymorphic marker at the 5′-end of the aldose reductase gene using polymerase chain reaction. No significant difference in the frequency of the putative risk allele Z-2 was found in patients of nephropathy and retinopathy groups compared with the uncomplicated group (32.2, 34.1 vs. 25.1%, respectively, P>0.05). Similarly, no difference was found in the frequency of the putative protective allele Z+2 among any of the study groups. In conclusion, the results of the study in Korean type 2 diabetic patients do not support the hypothesis that polymorphism at the 5′ end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular complications.
UR - http://www.scopus.com/inward/record.url?scp=0036143666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036143666&partnerID=8YFLogxK
U2 - 10.1016/S0168-8227(01)00299-6
DO - 10.1016/S0168-8227(01)00299-6
M3 - Article
C2 - 11796181
AN - SCOPUS:0036143666
VL - 55
SP - 151
EP - 157
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 2
ER -