(AC)n polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus

H. K. Park, C. W. Ahn, G. T. Lee, S. J. Kim, Y. D. Song, S. K. Lim, K. R. Kim, K. B. Huh, H. C. Lee

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Abstract

Recent studies suggest that the gene encoding aldose reductase, the enzyme that converts glucose to sorbitol, may confer susceptibility to microvascular disease. The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy. DNA from 127 Korean patients with type 2 diabetes was typed for an (AC)n dinucleotide repeat polymorphic marker at the 5′-end of the aldose reductase gene using polymerase chain reaction. No significant difference in the frequency of the putative risk allele Z-2 was found in patients of nephropathy and retinopathy groups compared with the uncomplicated group (32.2, 34.1 vs. 25.1%, respectively, P>0.05). Similarly, no difference was found in the frequency of the putative protective allele Z+2 among any of the study groups. In conclusion, the results of the study in Korean type 2 diabetic patients do not support the hypothesis that polymorphism at the 5′ end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular complications.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume55
Issue number2
DOIs
Publication statusPublished - 2002 Jan 22

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Aldehyde Reductase
Diabetes Complications
Type 2 Diabetes Mellitus
Genes
Alleles
Dinucleotide Repeats
Sorbitol
Diabetic Nephropathies
Diabetic Retinopathy
Glucose
Polymerase Chain Reaction
DNA
Enzymes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Park, H. K. ; Ahn, C. W. ; Lee, G. T. ; Kim, S. J. ; Song, Y. D. ; Lim, S. K. ; Kim, K. R. ; Huh, K. B. ; Lee, H. C. / (AC)n polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus. In: Diabetes Research and Clinical Practice. 2002 ; Vol. 55, No. 2. pp. 151-157.
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(AC)n polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus. / Park, H. K.; Ahn, C. W.; Lee, G. T.; Kim, S. J.; Song, Y. D.; Lim, S. K.; Kim, K. R.; Huh, K. B.; Lee, H. C.

In: Diabetes Research and Clinical Practice, Vol. 55, No. 2, 22.01.2002, p. 151-157.

Research output: Contribution to journalArticle

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AU - Song, Y. D.

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AU - Kim, K. R.

AU - Huh, K. B.

AU - Lee, H. C.

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N2 - Recent studies suggest that the gene encoding aldose reductase, the enzyme that converts glucose to sorbitol, may confer susceptibility to microvascular disease. The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy. DNA from 127 Korean patients with type 2 diabetes was typed for an (AC)n dinucleotide repeat polymorphic marker at the 5′-end of the aldose reductase gene using polymerase chain reaction. No significant difference in the frequency of the putative risk allele Z-2 was found in patients of nephropathy and retinopathy groups compared with the uncomplicated group (32.2, 34.1 vs. 25.1%, respectively, P>0.05). Similarly, no difference was found in the frequency of the putative protective allele Z+2 among any of the study groups. In conclusion, the results of the study in Korean type 2 diabetic patients do not support the hypothesis that polymorphism at the 5′ end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular complications.

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