Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain

Jae Wan Huh; Myung Min Choi; Han Lee Jang; Seung Ju Yang; Jung Kim Mi; Jene Choi; Ho Lee Kwan; Eun Lee Jong; Sung Woo Cho

doi:10.1016/j.jinorgbio.2005.06.032

Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain

Jae Wan Huh, Myung Min Choi, Han Lee Jang, Seung Ju Yang, Jung Kim Mi, Jene Choi, Ho Lee Kwan, Eun Lee Jong, Sung Woo Cho

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (k_cat/K_M) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.

Original language	English
Pages (from-to)	2088-2091
Number of pages	4
Journal	Journal of Inorganic Biochemistry
Volume	99
Issue number	10
DOIs	https://doi.org/10.1016/j.jinorgbio.2005.06.032
Publication status	Published - 2005 Oct

Bibliographical note

Funding Information:
This work was supported by Grants from the Korea Research Foundation (KRF-2002-005-E00002 and KRF-2004-005-C00008) to S.-W. Cho.

All Science Journal Classification (ASJC) codes

Biochemistry
Inorganic Chemistry

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title = "Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain",

abstract = "Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.",

author = "Huh, {Jae Wan} and Choi, {Myung Min} and Jang, {Han Lee} and Yang, {Seung Ju} and Mi, {Jung Kim} and Jene Choi and Kwan, {Ho Lee} and Jong, {Eun Lee} and Cho, {Sung Woo}",

note = "Funding Information: This work was supported by Grants from the Korea Research Foundation (KRF-2002-005-E00002 and KRF-2004-005-C00008) to S.-W. Cho.",

year = "2005",

month = oct,

doi = "10.1016/j.jinorgbio.2005.06.032",

language = "English",

volume = "99",

pages = "2088--2091",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

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T1 - Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain

AU - Huh, Jae Wan

AU - Choi, Myung Min

AU - Jang, Han Lee

AU - Yang, Seung Ju

AU - Mi, Jung Kim

AU - Choi, Jene

AU - Kwan, Ho Lee

AU - Jong, Eun Lee

AU - Cho, Sung Woo

N1 - Funding Information: This work was supported by Grants from the Korea Research Foundation (KRF-2002-005-E00002 and KRF-2004-005-C00008) to S.-W. Cho.

PY - 2005/10

Y1 - 2005/10

N2 - Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.

AB - Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.

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JO - Journal of Inorganic Biochemistry

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