Abstract
Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.
| Original language | English |
|---|---|
| Pages (from-to) | 2088-2091 |
| Number of pages | 4 |
| Journal | Journal of Inorganic Biochemistry |
| Volume | 99 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2005 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Inorganic Chemistry
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Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain. / Huh, Jae Wan; Choi, Myung Min; Jang, Han Lee; Yang, Seung Ju; Mi, Jung Kim; Choi, Jene; Kwan, Ho Lee; Jong, Eun Lee; Cho, Sung Woo.
In: Journal of Inorganic Biochemistry, Vol. 99, No. 10, 01.10.2005, p. 2088-2091.Research output: Contribution to journal › Article
TY - JOUR
T1 - Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain
AU - Huh, Jae Wan
AU - Choi, Myung Min
AU - Jang, Han Lee
AU - Yang, Seung Ju
AU - Mi, Jung Kim
AU - Choi, Jene
AU - Kwan, Ho Lee
AU - Jong, Eun Lee
AU - Cho, Sung Woo
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.
AB - Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.
UR - http://www.scopus.com/inward/record.url?scp=26044447171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26044447171&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2005.06.032
DO - 10.1016/j.jinorgbio.2005.06.032
M3 - Article
C2 - 16087240
AN - SCOPUS:26044447171
VL - 99
SP - 2088
EP - 2091
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 10
ER -