Abstract
Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.
Original language | English |
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Pages (from-to) | 2088-2091 |
Number of pages | 4 |
Journal | Journal of Inorganic Biochemistry |
Volume | 99 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 Oct |
Bibliographical note
Funding Information:This work was supported by Grants from the Korea Research Foundation (KRF-2002-005-E00002 and KRF-2004-005-C00008) to S.-W. Cho.
All Science Journal Classification (ASJC) codes
- Biochemistry
- Inorganic Chemistry