Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts

Tae Sung Park, Seung Tae Lee, Jin Seok Kim, Jaewoo Song, Kyung A. Lee, Sue Jung Kim, Yoon Mi Seok, Hyeon Ji Lee, Jeong Hyun Han, Jong Kee Kim, Eun Yup Lee, Jong Rak Choi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A 32-year-old pregnant woman in the 13th gestational week was brought to Severance Hospital with gum bleeding and easy bruising. Initial laboratory results revealed anemia and thrombocytopenia. In a peripheral blood smear, 81% of leukocytes were large, abnormal promyelocytes. Bone marrow aspiration showed a hypercellular marrow with packed leukemic promyelocytes, and chromosome study revealed a karyotype of 46,XX,t(15;17)(q22;q21)[10]/46,XX[10]. In addition, variant fusion transcripts of PML/RARA were detected in the marrow specimen. The patient was diagnosed with acute promyelocytic leukemia (APL) and was treated with all-trans retinoic acid (ATRA) and idarubicin. One month from the patient's initial diagnosis a follow-up bone marrow examination was performed, revealing complete remission (CR). We know of no previous reports of APL during pregnancy associated with variant PML/RARA fusion transcripts. Here, we describe a novel case of APL in a pregnant woman with a t(15;17) translocation and variant fusion transcripts.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalCancer genetics and cytogenetics
Volume188
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts'. Together they form a unique fingerprint.

  • Cite this

    Park, T. S., Lee, S. T., Kim, J. S., Song, J., Lee, K. A., Kim, S. J., Seok, Y. M., Lee, H. J., Han, J. H., Kim, J. K., Lee, E. Y., & Choi, J. R. (2009). Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts. Cancer genetics and cytogenetics, 188(1), 48-51. https://doi.org/10.1016/j.cancergencyto.2008.08.012