Acute pulmonary embolism: Retrospective cohort study of the predictive value of perfusion defect volume measured with dual-energy CT

Dong Jin Im, Jin Hur, Kyung Hwa Han, Hye Jeong Lee, Young Jin Kim, Woocheol Kwon, Byoung Wook Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE. The purposes of this study were to investigate dual-energy CT fndings predictive of clinical outcome and to determine the incremental risk stratifcation beneft of dual-energy CT fndings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism. MATERIALS AND METHODS. A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured. The primary endpoints were death within 30 days and pulmonary embolism-related death. RESULTS. A ventricular diameter ratio of 1 or greater was associated with increased risk of death within 30 days (hazard ratio, 3.822; p = 0.002) and pulmonary embolism-related death (hazard ratio, 18.051; p < 0.001). Relative perfusion defect volume was also associated with increased risk of death of any cause within 30 days (hazard ratio, 1.044; p = 0.014) and pulmonary embolism-related death (hazard ratio, 1.046; p = 0.017). However, the addition of relative perfusion defect volume to ventricular diameter ratio had no added beneft for prediction of death of any cause within 30 days (concordance statistic, 0.833 vs 0.815; p = 0.187) or pulmonary embolism-related death (concordance statistic, 0.873 vs 0.874; p = 0.866). CONCLUSION. Compared with ventricular diameter ratio alone, lung perfusion defect volume had no statistically signifcant added beneft for prediction of death of any cause within 30 days or of pulmonary embolism-related death among patients with acute PE.

Original languageEnglish
Pages (from-to)1015-1022
Number of pages8
JournalAmerican Journal of Roentgenology
Volume209
Issue number5
DOIs
Publication statusPublished - 2017 Nov

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Pulmonary Embolism
Cohort Studies
Retrospective Studies
Perfusion
Cause of Death
Lung

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Im, Dong Jin ; Hur, Jin ; Han, Kyung Hwa ; Lee, Hye Jeong ; Kim, Young Jin ; Kwon, Woocheol ; Choi, Byoung Wook. / Acute pulmonary embolism : Retrospective cohort study of the predictive value of perfusion defect volume measured with dual-energy CT. In: American Journal of Roentgenology. 2017 ; Vol. 209, No. 5. pp. 1015-1022.
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abstract = "OBJECTIVE. The purposes of this study were to investigate dual-energy CT fndings predictive of clinical outcome and to determine the incremental risk stratifcation beneft of dual-energy CT fndings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism. MATERIALS AND METHODS. A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured. The primary endpoints were death within 30 days and pulmonary embolism-related death. RESULTS. A ventricular diameter ratio of 1 or greater was associated with increased risk of death within 30 days (hazard ratio, 3.822; p = 0.002) and pulmonary embolism-related death (hazard ratio, 18.051; p < 0.001). Relative perfusion defect volume was also associated with increased risk of death of any cause within 30 days (hazard ratio, 1.044; p = 0.014) and pulmonary embolism-related death (hazard ratio, 1.046; p = 0.017). However, the addition of relative perfusion defect volume to ventricular diameter ratio had no added beneft for prediction of death of any cause within 30 days (concordance statistic, 0.833 vs 0.815; p = 0.187) or pulmonary embolism-related death (concordance statistic, 0.873 vs 0.874; p = 0.866). CONCLUSION. Compared with ventricular diameter ratio alone, lung perfusion defect volume had no statistically signifcant added beneft for prediction of death of any cause within 30 days or of pulmonary embolism-related death among patients with acute PE.",
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Acute pulmonary embolism : Retrospective cohort study of the predictive value of perfusion defect volume measured with dual-energy CT. / Im, Dong Jin; Hur, Jin; Han, Kyung Hwa; Lee, Hye Jeong; Kim, Young Jin; Kwon, Woocheol; Choi, Byoung Wook.

In: American Journal of Roentgenology, Vol. 209, No. 5, 11.2017, p. 1015-1022.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute pulmonary embolism

T2 - Retrospective cohort study of the predictive value of perfusion defect volume measured with dual-energy CT

AU - Im, Dong Jin

AU - Hur, Jin

AU - Han, Kyung Hwa

AU - Lee, Hye Jeong

AU - Kim, Young Jin

AU - Kwon, Woocheol

AU - Choi, Byoung Wook

PY - 2017/11

Y1 - 2017/11

N2 - OBJECTIVE. The purposes of this study were to investigate dual-energy CT fndings predictive of clinical outcome and to determine the incremental risk stratifcation beneft of dual-energy CT fndings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism. MATERIALS AND METHODS. A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured. The primary endpoints were death within 30 days and pulmonary embolism-related death. RESULTS. A ventricular diameter ratio of 1 or greater was associated with increased risk of death within 30 days (hazard ratio, 3.822; p = 0.002) and pulmonary embolism-related death (hazard ratio, 18.051; p < 0.001). Relative perfusion defect volume was also associated with increased risk of death of any cause within 30 days (hazard ratio, 1.044; p = 0.014) and pulmonary embolism-related death (hazard ratio, 1.046; p = 0.017). However, the addition of relative perfusion defect volume to ventricular diameter ratio had no added beneft for prediction of death of any cause within 30 days (concordance statistic, 0.833 vs 0.815; p = 0.187) or pulmonary embolism-related death (concordance statistic, 0.873 vs 0.874; p = 0.866). CONCLUSION. Compared with ventricular diameter ratio alone, lung perfusion defect volume had no statistically signifcant added beneft for prediction of death of any cause within 30 days or of pulmonary embolism-related death among patients with acute PE.

AB - OBJECTIVE. The purposes of this study were to investigate dual-energy CT fndings predictive of clinical outcome and to determine the incremental risk stratifcation beneft of dual-energy CT fndings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism. MATERIALS AND METHODS. A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured. The primary endpoints were death within 30 days and pulmonary embolism-related death. RESULTS. A ventricular diameter ratio of 1 or greater was associated with increased risk of death within 30 days (hazard ratio, 3.822; p = 0.002) and pulmonary embolism-related death (hazard ratio, 18.051; p < 0.001). Relative perfusion defect volume was also associated with increased risk of death of any cause within 30 days (hazard ratio, 1.044; p = 0.014) and pulmonary embolism-related death (hazard ratio, 1.046; p = 0.017). However, the addition of relative perfusion defect volume to ventricular diameter ratio had no added beneft for prediction of death of any cause within 30 days (concordance statistic, 0.833 vs 0.815; p = 0.187) or pulmonary embolism-related death (concordance statistic, 0.873 vs 0.874; p = 0.866). CONCLUSION. Compared with ventricular diameter ratio alone, lung perfusion defect volume had no statistically signifcant added beneft for prediction of death of any cause within 30 days or of pulmonary embolism-related death among patients with acute PE.

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