In this paper, we combine adaptive modulation and coding (AMC) with multiple input multiple output (MIMO) VBLAST multiplexing to improve the throughput performance of AMC in next generation mobile communication systems. In addition, we propose a system that adopts selection transmit diversity (STD) in the combined AMC-MIMO VBLAST system. The received signal-to-noise ratio (SNR) is improved by adopting STD techniques and an improved SNR increases a probability of selecting modulation and coding scheme (MCS) level that supports higher data rate. From the simulation results, the investigated MIMO-STD VBLAST system provides a throughput gain of 1Mbps compared with simply combined AMC-MIMO VBLAST system when the required SNR is 15dB. Also, the higher throughput is achieved by AMC-TD schemes and AMC-STTD scheme provides about 250kbps increase in throughput. And AMC-STD with 2 transmit antennas achieves about 420 kbps throughput improvement over the conventional AMC at 9dB SNR.