Addition of autogenous bone chips to deproteinized bovine bone mineral does not have additional benefit in lateral ridge augmentation—A preclinical in vivo experimental study

Young Woo Song, Hyun Jun Jung, Yin Zhe An, Ui Won Jung, Jung Seok Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: To compare the outcome after extensive lateral guided bone regeneration using deproteinized bovine bone mineral (DBBM) with or without autogenous bone chips in a canine model of chronic horizontal alveolar ridge defect. Materials and Methods: The second, third and fourth lower premolars of both sides were extracted, and the buccal bone walls were completely removed in five beagle dogs. After 4 weeks, DBBM particles mixed with autogenous bone chips at a ratio of 1:1 were grafted at one side (DBBM/Auto group), while DBBM particles alone were grafted at the contralateral side (DBBM group). The graft materials on both sides were covered by a resorbable collagen membrane and fixation pins. Microcomputed tomographic volume and histomorphometric analyses were performed at 16 weeks post-surgery. Results: The ridges of both groups were recovered horizontally, but new bone formation beyond the original ridge contour at the defect site was not found. The DBBM group exhibited a larger total radiographic augmented volume and new bone volume compared with the DBBM/Auto group, but the differences were minimal (p >.05). Histologically, the regenerated area and new bone area were also slightly larger without any statistical significance in the DBBM group than in the DBBM/Auto group (p >.05). Conclusion: The addition of autogenous bone chips to DBBM for lateral ridge augmentation may confer no advantage over grafting DBBM alone with respect to both space maintenance and de novo bone formation in dogs.

Original languageEnglish
Pages (from-to)1105-1114
Number of pages10
JournalClinical Oral Implants Research
Volume32
Issue number9
DOIs
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (NRF‐2019R1A2C4069942) and a grant of the Korea Health Technology R&D project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI20C2114). Particulated DBBM and resorbable collagen membrane used in this experiment were provided by Geistlich Pharma.

Funding Information:
The National Research Fund of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF‐2019R1A2C4069942) and the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI20C2114)

Funding Information:
The National Research Fund of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2019R1A2C4069942) and the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI20C2114) This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (NRF-2019R1A2C4069942) and a grant of the Korea Health Technology R&D project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI20C2114). Particulated DBBM and resorbable collagen membrane used in this experiment were provided by Geistlich Pharma.

Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

  • Oral Surgery

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