Additional targeted biopsy in clinically suspected prostate cancer: Prospective randomized comparison between contrast-enhanced ultrasound and sonoelastography guidance

Jieun Koh, Dae Chul Jung, Young Taik Oh, Moon Gyu Yoo, Songmi Noh, Kyung Hwa Han, Koon Ho Rha, Young Deuk Choi, Sung Joon Hong

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8 Citations (Scopus)


Our aim was to improve the detection of prostate cancer by evaluating whether contrast-enhanced ultrasound (CEUS) or sonoelastography (SE) is more helpful in guiding targeted biopsy (TB) performed before systematic biopsy (SB). A total of 52 patients suspected of having prostate cancer were prospectively included and randomly assigned to either the CEUS or SE group. Different, independent radiologists performed TB and twelve-core SB. Within each group, cancer detection rates based on core number were compared between SB and TB. We evaluated the effect of TB on core-based cancer detection rates between the CEUS and SE groups. Cancer detection was higher in overall TB cores 16.4% (28/171) than SB cores 11.4% (71/624) in both groups. In the SE group, TB cores revealed higher cancer detection than did SB cores from 4.49% (14/312) to 12.86% (9/70) (p = 0.01). Compared with CEUS, SE may improve detection rates when considering additional TB guidance methods.

Original languageEnglish
Pages (from-to)2836-2841
Number of pages6
JournalUltrasound in Medicine and Biology
Issue number11
Publication statusPublished - 2015 Nov


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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