Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors: An initial experience

Seung Hyun Lee, Jin Hur, Youngjin Kim, Hye Jeong Lee, Yoo Jin Hong, Byoung Wook Choi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. Materials and methods We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. Results 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p = 0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p = 0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p = 0.067 and 67.4 HU vs. 78.4 HU, p = 0.086, respectively). Conclusions Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors

Original languageEnglish
Pages (from-to)2043-2049
Number of pages7
JournalEuropean Journal of Radiology
Volume82
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1

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Tomography
Neoplasms
Iodine
Thorax
Pathology
Radiography
Research Personnel

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, Seung Hyun ; Hur, Jin ; Kim, Youngjin ; Lee, Hye Jeong ; Hong, Yoo Jin ; Choi, Byoung Wook. / Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors : An initial experience. In: European Journal of Radiology. 2013 ; Vol. 82, No. 11. pp. 2043-2049.
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abstract = "Objectives To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. Materials and methods We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. Results 10 patients (40{\%}) had benign pathology, while 15 (60{\%}) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p = 0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p = 0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p = 0.067 and 67.4 HU vs. 78.4 HU, p = 0.086, respectively). Conclusions Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors",
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Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors : An initial experience. / Lee, Seung Hyun; Hur, Jin; Kim, Youngjin; Lee, Hye Jeong; Hong, Yoo Jin; Choi, Byoung Wook.

In: European Journal of Radiology, Vol. 82, No. 11, 01.11.2013, p. 2043-2049.

Research output: Contribution to journalArticle

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T1 - Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors

T2 - An initial experience

AU - Lee, Seung Hyun

AU - Hur, Jin

AU - Kim, Youngjin

AU - Lee, Hye Jeong

AU - Hong, Yoo Jin

AU - Choi, Byoung Wook

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N2 - Objectives To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. Materials and methods We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. Results 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p = 0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p = 0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p = 0.067 and 67.4 HU vs. 78.4 HU, p = 0.086, respectively). Conclusions Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors

AB - Objectives To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. Materials and methods We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. Results 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p = 0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p = 0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p = 0.067 and 67.4 HU vs. 78.4 HU, p = 0.086, respectively). Conclusions Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors

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