Adenosine stress 64-and 256-row detector computed tomography angiography and perfusion imaging a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia

Richard T. George, Armin Arbab-Zadeh, Julie M. Miller, Kakuya Kitagawa, Hyuk Jae Chang, David A. Bluemke, Lewis Becker, Omair Yousuf, John Texter, Albert C. Lardo, João A.C. Lima

Research output: Contribution to journalArticle

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Abstract

Background-Multidetector computed tomography coronary angiography (CTA) is a robust method for the noninvasive diagnosis of coronary artery disease. However, in its current form, CTA is limited in its prediction of myocardial ischemia. The purpose of this study was to test whether adenosine stress computed tomography myocardial perfusion imaging (CTP), when added to CTA, can predict perfusion abnormalities caused by obstructive atherosclerosis. Methods and Results-Forty patients with a history of abnormal single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) underwent adenosine stress 64-row (n=24) or 256-row (n=16) detector CTP and CTA. A subset of 27 patients had invasive angiography available for quantitative coronary angiography. CTA and quantitative coronary angiography were evaluated for stenoses °50%, and SPECT-MPI was evaluated for fixed and reversible perfusion deficits using a 17-segment model. CTP images were analyzed for the transmural differences in perfusion using the transmural perfusion ratio (subendocardial attenuation density/subepicardial attenuation density). The sensitivity, specificity, positive predictive value, and negative predictive value for the combination of CTA and CTP to detect obstructive atherosclerosis causing perfusion abnormalities using the combination of quantitative coronary angiography and SPECT as the gold standard was 86%, 92%, 92%, and 85% in the per-patient analysis and 79%, 91%, 75%, and 92% in the per vessel/territory analysis, respectively. Conclusions-The combination of CTA and CTP can detect atherosclerosis causing perfusion abnormalities when compared with the combination of quantitative coronary angiography and SPECT. (Circ Cardiovasc Imaging. 2009;2:174-182.)

Original languageEnglish
Pages (from-to)174-182
Number of pages9
JournalCirculation: Cardiovascular Imaging
Volume2
Issue number3
DOIs
Publication statusPublished - 2009 May 1

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Perfusion Imaging
Coronary Angiography
Adenosine
Myocardial Ischemia
Atherosclerosis
Perfusion
Cytidine Triphosphate
Single-Photon Emission-Computed Tomography
Myocardial Perfusion Imaging
Computed Tomography Angiography
Multidetector Computed Tomography
Coronary Artery Disease
Angiography
Pathologic Constriction
Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

George, Richard T. ; Arbab-Zadeh, Armin ; Miller, Julie M. ; Kitagawa, Kakuya ; Chang, Hyuk Jae ; Bluemke, David A. ; Becker, Lewis ; Yousuf, Omair ; Texter, John ; Lardo, Albert C. ; Lima, João A.C. / Adenosine stress 64-and 256-row detector computed tomography angiography and perfusion imaging a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia. In: Circulation: Cardiovascular Imaging. 2009 ; Vol. 2, No. 3. pp. 174-182.
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abstract = "Background-Multidetector computed tomography coronary angiography (CTA) is a robust method for the noninvasive diagnosis of coronary artery disease. However, in its current form, CTA is limited in its prediction of myocardial ischemia. The purpose of this study was to test whether adenosine stress computed tomography myocardial perfusion imaging (CTP), when added to CTA, can predict perfusion abnormalities caused by obstructive atherosclerosis. Methods and Results-Forty patients with a history of abnormal single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) underwent adenosine stress 64-row (n=24) or 256-row (n=16) detector CTP and CTA. A subset of 27 patients had invasive angiography available for quantitative coronary angiography. CTA and quantitative coronary angiography were evaluated for stenoses °50{\%}, and SPECT-MPI was evaluated for fixed and reversible perfusion deficits using a 17-segment model. CTP images were analyzed for the transmural differences in perfusion using the transmural perfusion ratio (subendocardial attenuation density/subepicardial attenuation density). The sensitivity, specificity, positive predictive value, and negative predictive value for the combination of CTA and CTP to detect obstructive atherosclerosis causing perfusion abnormalities using the combination of quantitative coronary angiography and SPECT as the gold standard was 86{\%}, 92{\%}, 92{\%}, and 85{\%} in the per-patient analysis and 79{\%}, 91{\%}, 75{\%}, and 92{\%} in the per vessel/territory analysis, respectively. Conclusions-The combination of CTA and CTP can detect atherosclerosis causing perfusion abnormalities when compared with the combination of quantitative coronary angiography and SPECT. (Circ Cardiovasc Imaging. 2009;2:174-182.)",
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Adenosine stress 64-and 256-row detector computed tomography angiography and perfusion imaging a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia. / George, Richard T.; Arbab-Zadeh, Armin; Miller, Julie M.; Kitagawa, Kakuya; Chang, Hyuk Jae; Bluemke, David A.; Becker, Lewis; Yousuf, Omair; Texter, John; Lardo, Albert C.; Lima, João A.C.

In: Circulation: Cardiovascular Imaging, Vol. 2, No. 3, 01.05.2009, p. 174-182.

Research output: Contribution to journalArticle

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T1 - Adenosine stress 64-and 256-row detector computed tomography angiography and perfusion imaging a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia

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AU - Yousuf, Omair

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AU - Lardo, Albert C.

AU - Lima, João A.C.

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