Adipocyte biology in breast cancer: From silent bystander to active facilitator

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Adipocytes account for the largest proportion among the cells that comprise breast tissue; therefore, they are considered to be a critical cell type in the tumor microenvironment of breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but they also play an active role in the entire process of cancer development, progression, metastasis, and treatment response. Factors including the secretion of adipokines such as leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and hepatic growth factor, metabolic remodeling that supports the growth of breast cancer by transfer of fatty acids to increase mitochondrial β-oxidation, extracellular matrix remodeling and endotrophin production from type IV collagen, and cancer-associated fibroblast phenotype changes have all been implicated in this comprehensive process. Moreover, adipocytes may act as obstacles to therapy, as they are involved in mechanisms of resistance against various breast cancer treatments. Adipose tissues may also be a reservoir for dormant tumor cells during postsurgical autologous fat grafting. Thus, adipocytes, and the processes and pathways in which they are involved, could be effective therapeutic targets for breast cancer. In this review, we focus on the current understanding of adipocyte biology as it affects breast cancer.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalProgress in Lipid Research
Volume69
DOIs
Publication statusPublished - 2018 Jan

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Adipocytes
Tumors
Cells
Tissue
Breast Neoplasms
Adipokines
Oncology
Collagen Type IV
Adiponectin
Fibroblasts
Leptin
Interleukin-6
Intercellular Signaling Peptides and Proteins
Fatty Acids
Tumor Necrosis Factor-alpha
Fats
Oxidation
Neoplasms
Tumor Microenvironment
Extracellular Matrix

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

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abstract = "Adipocytes account for the largest proportion among the cells that comprise breast tissue; therefore, they are considered to be a critical cell type in the tumor microenvironment of breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but they also play an active role in the entire process of cancer development, progression, metastasis, and treatment response. Factors including the secretion of adipokines such as leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and hepatic growth factor, metabolic remodeling that supports the growth of breast cancer by transfer of fatty acids to increase mitochondrial β-oxidation, extracellular matrix remodeling and endotrophin production from type IV collagen, and cancer-associated fibroblast phenotype changes have all been implicated in this comprehensive process. Moreover, adipocytes may act as obstacles to therapy, as they are involved in mechanisms of resistance against various breast cancer treatments. Adipose tissues may also be a reservoir for dormant tumor cells during postsurgical autologous fat grafting. Thus, adipocytes, and the processes and pathways in which they are involved, could be effective therapeutic targets for breast cancer. In this review, we focus on the current understanding of adipocyte biology as it affects breast cancer.",
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Adipocyte biology in breast cancer : From silent bystander to active facilitator. / Choi, Junjeong; Cha, Yoon Jin; Koo, Ja Seung.

In: Progress in Lipid Research, Vol. 69, 01.2018, p. 11-20.

Research output: Contribution to journalReview article

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