Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis

Yoon Kang, Hee Jin Park, Mi I. Kang, Hyang Sun Lee, Sang Won Lee, Soo Kon Lee, YongBeom Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Introduction: Cardiovascular (CV) morbidity and mortality are increased in patients with rheumatoid arthritis (RA). Inflammation is thought to be an important factor in accelerated atherosclerosis in RA, whereas insulin resistance is a known risk factor for atherosclerosis in RA. We hypothesised that adipokines could be a link between inflammation, insulin resistance, and atherosclerosis in RA. Methods: The common carotid artery (CCA) intima-media thickness (IMT), CCA resistive index (RI), and carotid plaques were measured by ultrasonography in 192 patients with RA. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). Serum adiponectin, leptin, resistin, tumor necrosis factor-α, and interleukin (IL)-6 concentrations were determined. Results: The CCA RI was associated with CCA IMT and the estimated total plaque volume after adjustment for conventional CV risk factors. Among adipokines, resistin and IL-6 were correlated with inflammatory parameters. Leptin and leptin:adiponectin (L:A) ratio were correlated with metabolic risk factors, including HOMA-IR. And L:A ratio was related to the CCA RI after adjustment for conventional and nonconventional CV risk factors, including HOMA-IR, erythrocyte sedimentation rate and C-reactive protein.Conclusion: L:A ratio was associated with HOMA-IR and carotid RI. L:A ratio might be an independent factor for predicting cardiovascular risk in patients with RA.

Original languageEnglish
Article numberR194
JournalArthritis Research and Therapy
Volume15
Issue number6
DOIs
Publication statusPublished - 2013 Nov 19

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Carotid Artery Diseases
Adipokines
Leptin
Insulin Resistance
Rheumatoid Arthritis
Common Carotid Artery
Adiponectin
Inflammation
Homeostasis
Resistin
Atherosclerosis
Carotid Intima-Media Thickness
Interleukin-6
Blood Sedimentation
C-Reactive Protein
Ultrasonography
Tumor Necrosis Factor-alpha
Morbidity
Mortality
Serum

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Kang, Yoon ; Park, Hee Jin ; Kang, Mi I. ; Lee, Hyang Sun ; Lee, Sang Won ; Lee, Soo Kon ; Park, YongBeom. / Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis. In: Arthritis Research and Therapy. 2013 ; Vol. 15, No. 6.
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Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis. / Kang, Yoon; Park, Hee Jin; Kang, Mi I.; Lee, Hyang Sun; Lee, Sang Won; Lee, Soo Kon; Park, YongBeom.

In: Arthritis Research and Therapy, Vol. 15, No. 6, R194, 19.11.2013.

Research output: Contribution to journalArticle

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N2 - Introduction: Cardiovascular (CV) morbidity and mortality are increased in patients with rheumatoid arthritis (RA). Inflammation is thought to be an important factor in accelerated atherosclerosis in RA, whereas insulin resistance is a known risk factor for atherosclerosis in RA. We hypothesised that adipokines could be a link between inflammation, insulin resistance, and atherosclerosis in RA. Methods: The common carotid artery (CCA) intima-media thickness (IMT), CCA resistive index (RI), and carotid plaques were measured by ultrasonography in 192 patients with RA. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). Serum adiponectin, leptin, resistin, tumor necrosis factor-α, and interleukin (IL)-6 concentrations were determined. Results: The CCA RI was associated with CCA IMT and the estimated total plaque volume after adjustment for conventional CV risk factors. Among adipokines, resistin and IL-6 were correlated with inflammatory parameters. Leptin and leptin:adiponectin (L:A) ratio were correlated with metabolic risk factors, including HOMA-IR. And L:A ratio was related to the CCA RI after adjustment for conventional and nonconventional CV risk factors, including HOMA-IR, erythrocyte sedimentation rate and C-reactive protein.Conclusion: L:A ratio was associated with HOMA-IR and carotid RI. L:A ratio might be an independent factor for predicting cardiovascular risk in patients with RA.

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