Adiponectin: The potential regulator and therapeutic target of obesity and alzheimer’s disease

Jong Youl Kim, Sumit Barua, Ye Jun Jeong, Jong Eun Lee

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer’s disease (AD). AD, a degenerative brain disease, is the most common cause of dementia and is characterized by the presence of extracellular amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles disposition. Some studies have recently demonstrated that Aβ and tau cannot fully explain the pathophysiological development of AD and that metabolic disease factors, such as insulin, adiponectin, and antioxidants, are important for the sporadic onset of nongenetic AD. Obesity prevention and treatment can be an efficacious and safe approach to AD prevention. Adiponectin is a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation. It has been shown to be inversely correlated with adipose tissue dysfunction and may enhance the risk of AD because a range of neuroprotection adiponectin mechanisms is related to AD pathology alleviation. In this study, we summarize the recent progress that addresses the beneficial effects and potential mechanisms of adiponectin in AD. Furthermore, we review recent studies on the diverse medications of adiponectin that could possibly be related to AD treatment, with a focus on their association with adiponectin. A better understanding of the neuroprotection roles of adiponectin will help clarify the precise underlying mechanism of AD development and progression.

Original languageEnglish
Article number6419
Pages (from-to)1-20
Number of pages20
JournalInternational journal of molecular sciences
Issue number17
Publication statusPublished - 2020 Sept 1

Bibliographical note

Funding Information:
Funding: This study was supported by a grant from the National Research Foundation of Korea (NRF) through a grant funded by the Ministry of Science, ICT, and Future Planning (NRF-2017R1A2B2005350).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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