Adipose-derived stem cells as a new therapeutic modality for ageing skin

Jae Hong Kim, Minyoung Jung, Hyun Soo Kim, Yong Man Kim, Eung Ho Choi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Stem cells are undifferentiated cells, which have the important properties of self-renewal and differentiation. Adipose-derived stem cells (ADSC) have relative advantages in accessibility and abundance compared to other kinds of stem cells. Regeneration therapy using ADSC has received attention in the treatment of various dermatologic diseases. In previous studies, ADSC were shown to have antioxidant, whitening and wound-healing effects in the skin through secretion of growth factors and by activating fibroblasts. In this study, we investigated whether ADSC could be used as an anti-ageing therapy, especially by dermal collagen synthesis and angiogenesis. Subcutaneous injection of ADSC significantly increased collagen synthesis in hairless mice, and dermal thickness, collagen density and fibroblast number also increased. In addition, procollagen type I protein and mRNA expression increased, which accounts for the increased dermal collagen density. Angiogenesis, which was visualized by CD31 and NG2 immunofluorescence stains, also increased in ADSC-treated skin. Our results suggest that ADSC therapy may be useful in ageing skin. Its effects are mainly mediated by stimulating collagen synthesis in dermal fibroblasts and increasing angiogenesis.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalExperimental Dermatology
Volume20
Issue number5
DOIs
Publication statusPublished - 2011 May 1

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Skin Aging
Stem cells
Skin
Stem Cells
Aging of materials
Collagen
Fibroblasts
Therapeutics
Hairless Mouse
Fibroblast Growth Factors
Subcutaneous Injections
Cell- and Tissue-Based Therapy
Collagen Type I
Wound Healing
Fluorescent Antibody Technique
Regeneration
Intercellular Signaling Peptides and Proteins
Coloring Agents
Antioxidants
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Kim, Jae Hong ; Jung, Minyoung ; Kim, Hyun Soo ; Kim, Yong Man ; Choi, Eung Ho. / Adipose-derived stem cells as a new therapeutic modality for ageing skin. In: Experimental Dermatology. 2011 ; Vol. 20, No. 5. pp. 383-387.
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Adipose-derived stem cells as a new therapeutic modality for ageing skin. / Kim, Jae Hong; Jung, Minyoung; Kim, Hyun Soo; Kim, Yong Man; Choi, Eung Ho.

In: Experimental Dermatology, Vol. 20, No. 5, 01.05.2011, p. 383-387.

Research output: Contribution to journalArticle

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