Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer

Is it beneficial?

Jin Soo Kim, Namkyu Kim, Byung Soh Min, Hyuk Hur, Joong Bae Ahn, Ki Chang Keum

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial. We evaluated the effect of adjuvant chemoradiotherapy (CRT) versus chemotherapy (CT) alone on the local recurrence and survival of patients with stage IIA rectal cancer after TME. Methods: Between 1996 and 2004, patients with stage IIA rectal cancer who received adjuvant CT (n=29) or CRT (n=122) following TME were enrolled. Oncologic outcomes were compared between groups, and risk factors for local recurrence and overall survival rates were analyzed. Results: The median follow-up period was 78 months. No significant differences were observed in the 5-year local recurrence (3.4% versus 9.0%; P=0.348) or 5-year overall survival rates (86.2% versus 80.3%; P=0.924) between CT and CRT. However, involvement of the circumferential resection margin and age >60 years were associated with adverse oncologic outcomes. Conclusions: Additional postoperative radiotherapy did not alter local recurrence or survival after TME in patients with stage IIA rectal cancer. Postoperative radiation may be an overtreatment as an adjuvant therapy in patients with stage IIA rectal cancer if they had no other risk factors. However, randomized controlled trials are warranted to confirm this suggestion.

Original languageEnglish
Pages (from-to)1103-1110
Number of pages8
JournalInternational Journal of Colorectal Disease
Volume25
Issue number9
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Adjuvant Radiotherapy
Rectal Neoplasms
Recurrence
Chemoradiotherapy
Survival Rate
Adjuvant Chemoradiotherapy
Drug Therapy
Survival
Adjuvant Chemotherapy
Radiotherapy
Randomized Controlled Trials
Radiation

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Jin Soo ; Kim, Namkyu ; Min, Byung Soh ; Hur, Hyuk ; Ahn, Joong Bae ; Keum, Ki Chang. / Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer : Is it beneficial?. In: International Journal of Colorectal Disease. 2010 ; Vol. 25, No. 9. pp. 1103-1110.
@article{958939122cb14da79b6da02b009c128c,
title = "Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer: Is it beneficial?",
abstract = "Purpose: The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial. We evaluated the effect of adjuvant chemoradiotherapy (CRT) versus chemotherapy (CT) alone on the local recurrence and survival of patients with stage IIA rectal cancer after TME. Methods: Between 1996 and 2004, patients with stage IIA rectal cancer who received adjuvant CT (n=29) or CRT (n=122) following TME were enrolled. Oncologic outcomes were compared between groups, and risk factors for local recurrence and overall survival rates were analyzed. Results: The median follow-up period was 78 months. No significant differences were observed in the 5-year local recurrence (3.4{\%} versus 9.0{\%}; P=0.348) or 5-year overall survival rates (86.2{\%} versus 80.3{\%}; P=0.924) between CT and CRT. However, involvement of the circumferential resection margin and age >60 years were associated with adverse oncologic outcomes. Conclusions: Additional postoperative radiotherapy did not alter local recurrence or survival after TME in patients with stage IIA rectal cancer. Postoperative radiation may be an overtreatment as an adjuvant therapy in patients with stage IIA rectal cancer if they had no other risk factors. However, randomized controlled trials are warranted to confirm this suggestion.",
author = "Kim, {Jin Soo} and Namkyu Kim and Min, {Byung Soh} and Hyuk Hur and Ahn, {Joong Bae} and Keum, {Ki Chang}",
year = "2010",
month = "9",
day = "1",
doi = "10.1007/s00384-010-0970-1",
language = "English",
volume = "25",
pages = "1103--1110",
journal = "International Journal of Colorectal Disease",
issn = "0179-1958",
publisher = "Springer Verlag",
number = "9",

}

Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer : Is it beneficial? / Kim, Jin Soo; Kim, Namkyu; Min, Byung Soh; Hur, Hyuk; Ahn, Joong Bae; Keum, Ki Chang.

In: International Journal of Colorectal Disease, Vol. 25, No. 9, 01.09.2010, p. 1103-1110.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer

T2 - Is it beneficial?

AU - Kim, Jin Soo

AU - Kim, Namkyu

AU - Min, Byung Soh

AU - Hur, Hyuk

AU - Ahn, Joong Bae

AU - Keum, Ki Chang

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Purpose: The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial. We evaluated the effect of adjuvant chemoradiotherapy (CRT) versus chemotherapy (CT) alone on the local recurrence and survival of patients with stage IIA rectal cancer after TME. Methods: Between 1996 and 2004, patients with stage IIA rectal cancer who received adjuvant CT (n=29) or CRT (n=122) following TME were enrolled. Oncologic outcomes were compared between groups, and risk factors for local recurrence and overall survival rates were analyzed. Results: The median follow-up period was 78 months. No significant differences were observed in the 5-year local recurrence (3.4% versus 9.0%; P=0.348) or 5-year overall survival rates (86.2% versus 80.3%; P=0.924) between CT and CRT. However, involvement of the circumferential resection margin and age >60 years were associated with adverse oncologic outcomes. Conclusions: Additional postoperative radiotherapy did not alter local recurrence or survival after TME in patients with stage IIA rectal cancer. Postoperative radiation may be an overtreatment as an adjuvant therapy in patients with stage IIA rectal cancer if they had no other risk factors. However, randomized controlled trials are warranted to confirm this suggestion.

AB - Purpose: The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial. We evaluated the effect of adjuvant chemoradiotherapy (CRT) versus chemotherapy (CT) alone on the local recurrence and survival of patients with stage IIA rectal cancer after TME. Methods: Between 1996 and 2004, patients with stage IIA rectal cancer who received adjuvant CT (n=29) or CRT (n=122) following TME were enrolled. Oncologic outcomes were compared between groups, and risk factors for local recurrence and overall survival rates were analyzed. Results: The median follow-up period was 78 months. No significant differences were observed in the 5-year local recurrence (3.4% versus 9.0%; P=0.348) or 5-year overall survival rates (86.2% versus 80.3%; P=0.924) between CT and CRT. However, involvement of the circumferential resection margin and age >60 years were associated with adverse oncologic outcomes. Conclusions: Additional postoperative radiotherapy did not alter local recurrence or survival after TME in patients with stage IIA rectal cancer. Postoperative radiation may be an overtreatment as an adjuvant therapy in patients with stage IIA rectal cancer if they had no other risk factors. However, randomized controlled trials are warranted to confirm this suggestion.

UR - http://www.scopus.com/inward/record.url?scp=77955419656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955419656&partnerID=8YFLogxK

U2 - 10.1007/s00384-010-0970-1

DO - 10.1007/s00384-010-0970-1

M3 - Article

VL - 25

SP - 1103

EP - 1110

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

SN - 0179-1958

IS - 9

ER -