Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production

Hoon Son Gi, Sooyoung Chung, Kyoung Choe Han, Hee Dae Kim, Sun Mee Baik, Hankyu Lee, Han Woong Lee, Sukwoo Choi, Woong Sun, Hyun Kim, Sehyung Cho, Ho Lee Kun, Kyungjin Kim

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a robust daily oscillation, which has been thought to be driven by the master circadian clock in the suprachiasmatic nucleus of the hypothalamus via the hypothalamus-pituitary-adrenal axis. However, we show that the adrenal gland has its own clock and that the peripheral clockwork is tightly linked to steroidogenesis by the steroidogenic acute regulatory protein. Examination of mice with adrenal-specific knockdown of the canonical clock protein BMAL1 reveals that the adrenal clock machinery is required for circadian GC production. Furthermore, behavioral rhythmicity is drastically affected in these animals, together with altered expression of Period1, but not Period2, in several peripheral organs. We conclude that the adrenal peripheral clock plays an essential role in harmonizing the mammalian circadian timing system by generating a robust circadian GC rhythm.

Original languageEnglish
Pages (from-to)20970-20975
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number52
DOIs
Publication statusPublished - 2008 Dec 30

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Circadian Rhythm
Glucocorticoids
Circadian Clocks
Steroids
ARNTL Transcription Factors
Hypothalamus
Suprachiasmatic Nucleus
Periodicity
Adrenal Glands

All Science Journal Classification (ASJC) codes

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Cite this

Gi, Hoon Son ; Chung, Sooyoung ; Han, Kyoung Choe ; Kim, Hee Dae ; Baik, Sun Mee ; Lee, Hankyu ; Lee, Han Woong ; Choi, Sukwoo ; Sun, Woong ; Kim, Hyun ; Cho, Sehyung ; Kun, Ho Lee ; Kim, Kyungjin. / Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 52. pp. 20970-20975.
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Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production. / Gi, Hoon Son; Chung, Sooyoung; Han, Kyoung Choe; Kim, Hee Dae; Baik, Sun Mee; Lee, Hankyu; Lee, Han Woong; Choi, Sukwoo; Sun, Woong; Kim, Hyun; Cho, Sehyung; Kun, Ho Lee; Kim, Kyungjin.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 52, 30.12.2008, p. 20970-20975.

Research output: Contribution to journalArticle

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AU - Han, Kyoung Choe

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AU - Lee, Hankyu

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AU - Choi, Sukwoo

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AU - Kim, Kyungjin

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