Advanced gastric carcinoma with signet ring cell histology

Chen Li, Sungsoo Kim, Ji Fu Lai, Woo Jin Hyung, Won Hyuk Choi, Seung Ho Choi, Sung Hoon Noh

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalOncology
Volume72
Issue number1-2
DOIs
Publication statusPublished - 2007 Nov 1

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Signet Ring Cell Carcinoma
Stomach
Histology
Adenocarcinoma
Neoplasm Metastasis
Lymph Nodes
Neoplasms
Lymph Node Excision
Multivariate Analysis
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Li, C., Kim, S., Lai, J. F., Hyung, W. J., Choi, W. H., Choi, S. H., & Noh, S. H. (2007). Advanced gastric carcinoma with signet ring cell histology. Oncology, 72(1-2), 64-68. https://doi.org/10.1159/000111096
Li, Chen ; Kim, Sungsoo ; Lai, Ji Fu ; Hyung, Woo Jin ; Choi, Won Hyuk ; Choi, Seung Ho ; Noh, Sung Hoon. / Advanced gastric carcinoma with signet ring cell histology. In: Oncology. 2007 ; Vol. 72, No. 1-2. pp. 64-68.
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abstract = "Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9{\%}) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4{\%}, compared with 50.1{\%} in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.",
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Li, C, Kim, S, Lai, JF, Hyung, WJ, Choi, WH, Choi, SH & Noh, SH 2007, 'Advanced gastric carcinoma with signet ring cell histology', Oncology, vol. 72, no. 1-2, pp. 64-68. https://doi.org/10.1159/000111096

Advanced gastric carcinoma with signet ring cell histology. / Li, Chen; Kim, Sungsoo; Lai, Ji Fu; Hyung, Woo Jin; Choi, Won Hyuk; Choi, Seung Ho; Noh, Sung Hoon.

In: Oncology, Vol. 72, No. 1-2, 01.11.2007, p. 64-68.

Research output: Contribution to journalArticle

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N2 - Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.

AB - Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.

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Li C, Kim S, Lai JF, Hyung WJ, Choi WH, Choi SH et al. Advanced gastric carcinoma with signet ring cell histology. Oncology. 2007 Nov 1;72(1-2):64-68. https://doi.org/10.1159/000111096