Abstract
Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.
| Original language | English |
|---|---|
| Pages (from-to) | 64-68 |
| Number of pages | 5 |
| Journal | Oncology |
| Volume | 72 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2007 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Advanced gastric carcinoma with signet ring cell histology. / Li, Chen; Kim, Sungsoo; Lai, Ji Fu; Hyung, Woo Jin; Choi, Won Hyuk; Choi, Seung Ho; Noh, Sung Hoon.
In: Oncology, Vol. 72, No. 1-2, 01.11.2007, p. 64-68.Research output: Contribution to journal › Article
TY - JOUR
T1 - Advanced gastric carcinoma with signet ring cell histology
AU - Li, Chen
AU - Kim, Sungsoo
AU - Lai, Ji Fu
AU - Hyung, Woo Jin
AU - Choi, Won Hyuk
AU - Choi, Seung Ho
AU - Noh, Sung Hoon
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.
AB - Background: Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not on biological behavior. This study compared the clinicopathological features and prognosis of advanced SRC with non-signet ring cell adenocarcinoma (NSRC) of the stomach. Methods: We reviewed the records of 4,759 consecutive patients diagnosed with advanced gastric adenocarcinoma who were resected surgically from 1987 to 2003. Of these, 662 patients (13.9%) had SRC and were compared with 4,097 patients with NSRC. Results: Significant differences were noted in tumor size, Borrmann type, depth of invasion, lymph node metastasis, peritoneal dissemination and TNM stage. The cumulative 5-year survival rate for advanced SRC was 42.4%, compared with 50.1% in NSRC (p = 0.009). Multivariate analysis showed that tumor size ≥5 cm, Borrmann III and IV, T3-4 invasion and SRC histology were independent risk factors for lymph node metastasis. Depth of invasion, lymph node metastasis, hepatic and peritoneal metastasis and surgical curability were significant factors affecting survival. SRC histology alone was not an independent prognostic factor. Conclusions: Advanced gastric SRC tends toward deeper tumor invasion and more lymph node and peritoneal metastasis than NSRC. Advanced gastric SRC had a worse prognosis than NSRC. Therefore, curative surgical operation with extended lymph node dissection is recommended.
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UR - http://www.scopus.com/inward/citedby.url?scp=37049007843&partnerID=8YFLogxK
U2 - 10.1159/000111096
DO - 10.1159/000111096
M3 - Article
C2 - 18004078
AN - SCOPUS:37049007843
VL - 72
SP - 64
EP - 68
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 1-2
ER -