Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

Kyung Min Kim, Ju Weon Lee, Sunhee Kim, Francisco Vitor Santos da Silva, Andreas Seidel-Morgenstern, Chang Ha Lee

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high-purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.

Original languageEnglish
Pages (from-to)2163-2178
Number of pages16
JournalChemical Engineering and Technology
Issue number12
Publication statusPublished - 2017 Dec

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support of the Defense Acquisition Program Administration (DAPA), Agency of Defense Development (ADD) of Korea, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil for supporting this work.

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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