Advances and Innovations of 3D Bioprinting Skin

Moon Sung Kang, Jinju Jang, Hyo Jung Jo, Won Hyeon Kim, Bongju Kim, Heoung Jae Chun, Dohyung Lim, Dong Wook Han

Research output: Contribution to journalReview articlepeer-review


Three-dimensional (3D) bioprinted skin equivalents are highlighted as the new gold standard for alternative models to animal testing, as well as full-thickness wound healing. In this review, we focus on the advances and innovations of 3D bioprinting skin for skin regeneration, within the last five years. After a brief introduction to skin anatomy, 3D bioprinting methods and the remarkable features of recent studies are classified as advances in materials, structures, and functions. We will discuss several ways to improve the clinical potential of 3D bioprinted skin, with state-of-the-art printing technology and novel biomaterials. After the breakthrough in the bottleneck of the current studies, highly developed skin can be fabricated, comprising stratified epidermis, dermis, and hypodermis with blood vessels, nerves, muscles, and skin appendages. We hope that this review will be priming water for future research and clinical applications, that will guide us to break new ground for the next generation of skin regeneration.

Original languageEnglish
Article number55
Issue number1
Publication statusPublished - 2023 Jan

Bibliographical note

Funding Information:
This work was supported by the Technology Innovation Program (20014399, Development of Photo-Curable Polymer Composites for 3D Printed Scaffolds and Barriers for Bone Defect Treatment) funded by the Ministry of Trade, Industry & Energy (MOTIE, Republic of Korea) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1A2C2006013).

Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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