Advances in Management of Intestinal Behçet’s Disease: A Perspective from Gastroenterologists

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3 Citations (Scopus)


Intestinal Behçet’s disease (intestinal BD) is a rare chronic inflammatory disorder of the intestine that is characterized by recurrent intestinal manifestations with other systemic features of BD. Intestinal BD is diagnosed when a typically shaped ulcer is observed in the gastrointestinal tract, and the clinical findings meet the diagnostic criteria for BD. Owing to the small number of patients, intestinal BD is easily underestimated. On the other hand, but it often requires surgical treatment because of severe complications, including intestinal perforations or massive bleeding. The same treatment strategies used for inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are used for intestinal BD. 5-Aminosalicylic acids, corticosteroids, and immunomodulators are considered conventional therapies, but a considerable number of patients eventually become unresponsive to these pharmaceutical treatments. Recently, biologic agents, such as anti-tumor necrosis factor-alpha inhibitors, have also been suggested as a new treatment option for intestinal BD. This article reviews the pathogenesis and diagnosis of intestinal BD and the current treatment strategies that are expected to be useful for rheumatologic specialists.

Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalJournal of Rheumatic Diseases
Issue number1
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
The author wishes to thank Sinyoung Park, who assisted in collecting and analyzing the related literature, and writing and revising the manuscript.

Publisher Copyright:
Copyright © 2021 by The Korean College of Rheumatology. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Rheumatology


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