Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis

Se Jin Park, Jin Soon Suh, Jun Ho Lee, Jung Won Lee, Seong Heon Kim, Kyoung Hee Han, Jaeil Shin

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Henoch-Schönlein purpura (HSP) is a leukocytoclastic vasculitis classically characterized by palpable purpura, arthritis, abdominal pain and renal disease. In this article, we summarize our current understanding of the pathogenesis of HSP and the implications for improving its diagnosis. Although the pathogenesis of HSP is not fully understood yet, exciting new information has emerged in recent years, leading to a better understanding of its pathogenesis. Here, we discuss genetic predisposition, immunoglobulins with a particular emphasis on IgA1, activated complements, cytokines and chemokines, abnormal coagulation and autoantibodies in the underlying pathogenic mechanisms. Finally, diagnostic criteria for HSP developed by institutions such as the American College of Rheumatology and the European League against Rheumatism/Paediatric Rheumatology European Society were proposed to improve early detection and diagnosis.

Original languageEnglish
Pages (from-to)1223-1238
Number of pages16
JournalExpert Review of Clinical Immunology
Volume9
Issue number12
DOIs
Publication statusPublished - 2013 Nov 25

Fingerprint

Schoenlein-Henoch Purpura
Purpura
Rheumatology
Genetic Predisposition to Disease
Rheumatic Diseases
Chemokines
Autoantibodies
Immunoglobulin A
Abdominal Pain
Arthritis
Immunoglobulins
Early Diagnosis
Pediatrics
Cytokines
Kidney

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Park, Se Jin ; Suh, Jin Soon ; Lee, Jun Ho ; Lee, Jung Won ; Kim, Seong Heon ; Han, Kyoung Hee ; Shin, Jaeil. / Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis. In: Expert Review of Clinical Immunology. 2013 ; Vol. 9, No. 12. pp. 1223-1238.
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Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis. / Park, Se Jin; Suh, Jin Soon; Lee, Jun Ho; Lee, Jung Won; Kim, Seong Heon; Han, Kyoung Hee; Shin, Jaeil.

In: Expert Review of Clinical Immunology, Vol. 9, No. 12, 25.11.2013, p. 1223-1238.

Research output: Contribution to journalReview article

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