Abstract
Henoch-Schönlein purpura (HSP) is a leukocytoclastic vasculitis classically characterized by palpable purpura, arthritis, abdominal pain and renal disease. In this article, we summarize our current understanding of the pathogenesis of HSP and the implications for improving its diagnosis. Although the pathogenesis of HSP is not fully understood yet, exciting new information has emerged in recent years, leading to a better understanding of its pathogenesis. Here, we discuss genetic predisposition, immunoglobulins with a particular emphasis on IgA1, activated complements, cytokines and chemokines, abnormal coagulation and autoantibodies in the underlying pathogenic mechanisms. Finally, diagnostic criteria for HSP developed by institutions such as the American College of Rheumatology and the European League against Rheumatism/Paediatric Rheumatology European Society were proposed to improve early detection and diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1223-1238 |
| Number of pages | 16 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 9 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2013 Nov 25 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis. / Park, Se Jin; Suh, Jin Soon; Lee, Jun Ho; Lee, Jung Won; Kim, Seong Heon; Han, Kyoung Hee; Shin, Jaeil.
In: Expert Review of Clinical Immunology, Vol. 9, No. 12, 25.11.2013, p. 1223-1238.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis
AU - Park, Se Jin
AU - Suh, Jin Soon
AU - Lee, Jun Ho
AU - Lee, Jung Won
AU - Kim, Seong Heon
AU - Han, Kyoung Hee
AU - Shin, Jaeil
PY - 2013/11/25
Y1 - 2013/11/25
N2 - Henoch-Schönlein purpura (HSP) is a leukocytoclastic vasculitis classically characterized by palpable purpura, arthritis, abdominal pain and renal disease. In this article, we summarize our current understanding of the pathogenesis of HSP and the implications for improving its diagnosis. Although the pathogenesis of HSP is not fully understood yet, exciting new information has emerged in recent years, leading to a better understanding of its pathogenesis. Here, we discuss genetic predisposition, immunoglobulins with a particular emphasis on IgA1, activated complements, cytokines and chemokines, abnormal coagulation and autoantibodies in the underlying pathogenic mechanisms. Finally, diagnostic criteria for HSP developed by institutions such as the American College of Rheumatology and the European League against Rheumatism/Paediatric Rheumatology European Society were proposed to improve early detection and diagnosis.
AB - Henoch-Schönlein purpura (HSP) is a leukocytoclastic vasculitis classically characterized by palpable purpura, arthritis, abdominal pain and renal disease. In this article, we summarize our current understanding of the pathogenesis of HSP and the implications for improving its diagnosis. Although the pathogenesis of HSP is not fully understood yet, exciting new information has emerged in recent years, leading to a better understanding of its pathogenesis. Here, we discuss genetic predisposition, immunoglobulins with a particular emphasis on IgA1, activated complements, cytokines and chemokines, abnormal coagulation and autoantibodies in the underlying pathogenic mechanisms. Finally, diagnostic criteria for HSP developed by institutions such as the American College of Rheumatology and the European League against Rheumatism/Paediatric Rheumatology European Society were proposed to improve early detection and diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=84887869986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887869986&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2013.850028
DO - 10.1586/1744666X.2013.850028
M3 - Review article
C2 - 24215411
AN - SCOPUS:84887869986
VL - 9
SP - 1223
EP - 1238
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 12
ER -