Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: A randomized controlled trial

So Jung Lee, Anthony R. Deldin, David White, Yoon Myung Kim, Ingrid Libman, Michelle Rivera-Vega, Jennifer L. Kuk, Sandra Sandoval, Chris Boesch, Silva Arslanian

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m2·min-1) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (- 1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm2) and intrahepatic lipid (Δ -1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg-1·min-1 per (μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.

Original languageEnglish
Pages (from-to)E1222-E1229
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume305
Issue number10
DOIs
Publication statusPublished - 2013 Nov 15

Fingerprint

Intra-Abdominal Fat
Insulin Resistance
Randomized Controlled Trials
Exercise
Lipids
Adiposity
Weight Loss
Caloric Restriction
Body Weight Changes
Glucose Clamp Technique
Abdominal Obesity
Waist Circumference
Adipose Tissue
Obesity
Fats
Control Groups
Liver

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Lee, So Jung ; Deldin, Anthony R. ; White, David ; Kim, Yoon Myung ; Libman, Ingrid ; Rivera-Vega, Michelle ; Kuk, Jennifer L. ; Sandoval, Sandra ; Boesch, Chris ; Arslanian, Silva. / Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls : A randomized controlled trial. In: American Journal of Physiology - Endocrinology and Metabolism. 2013 ; Vol. 305, No. 10. pp. E1222-E1229.
@article{0c506a408725492c8ee3b2e9cb85bd5c,
title = "Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: A randomized controlled trial",
abstract = "It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m2·min-1) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (- 1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat ({\%}) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm2) and intrahepatic lipid (Δ -1.70 ± 0.74{\%}) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg-1·min-1 per (μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.",
author = "Lee, {So Jung} and Deldin, {Anthony R.} and David White and Kim, {Yoon Myung} and Ingrid Libman and Michelle Rivera-Vega and Kuk, {Jennifer L.} and Sandra Sandoval and Chris Boesch and Silva Arslanian",
year = "2013",
month = "11",
day = "15",
doi = "10.1152/ajpendo.00285.2013",
language = "English",
volume = "305",
pages = "E1222--E1229",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "10",

}

Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls : A randomized controlled trial. / Lee, So Jung; Deldin, Anthony R.; White, David; Kim, Yoon Myung; Libman, Ingrid; Rivera-Vega, Michelle; Kuk, Jennifer L.; Sandoval, Sandra; Boesch, Chris; Arslanian, Silva.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 305, No. 10, 15.11.2013, p. E1222-E1229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls

T2 - A randomized controlled trial

AU - Lee, So Jung

AU - Deldin, Anthony R.

AU - White, David

AU - Kim, Yoon Myung

AU - Libman, Ingrid

AU - Rivera-Vega, Michelle

AU - Kuk, Jennifer L.

AU - Sandoval, Sandra

AU - Boesch, Chris

AU - Arslanian, Silva

PY - 2013/11/15

Y1 - 2013/11/15

N2 - It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m2·min-1) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (- 1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm2) and intrahepatic lipid (Δ -1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg-1·min-1 per (μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.

AB - It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m2·min-1) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (- 1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm2) and intrahepatic lipid (Δ -1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg-1·min-1 per (μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.

UR - http://www.scopus.com/inward/record.url?scp=84887591482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887591482&partnerID=8YFLogxK

U2 - 10.1152/ajpendo.00285.2013

DO - 10.1152/ajpendo.00285.2013

M3 - Article

C2 - 24045865

AN - SCOPUS:84887591482

VL - 305

SP - E1222-E1229

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 10

ER -