Age-dependent changes of gene expression in the Drosophila head

Se Nyun Kim, Ji Hwan Rhee, Young Hwa Song, Dong Yoon Park, Mina Hwang, Sung Ll Lee, Ja Eun Kim, Byung Soo Gim, Jeong Ho Yoon, Young-Joon Kim, Jeongsil Kim-Ha

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Previous gene expression profiling studies in Drosophila have provided clues for understanding the aging process at the gene expression level. For a detailed understanding, studies of specific regions of the body are necessary. We therefore employed microarray analysis to examine gene expression changes in the Drosophila head during aging. Six hundred and eighty-four of the 5405 genes present in the microarray showed significant age-dependent changes as determined by significance analysis of microarray (SAM) (q < 0.05). The biological significance of the changes was analyzed using the gene annotations provided by the Gene Ontology Consortium. Major changes involved genes affecting energy metabolism (proton transport, energy pathways, oxidative phosphorylation) and neuronal function, especially responses to light. Genes involved in protein catabolism and several other metabolic processes also showed age-dependent changes. Most of the changes were reductions in gene expression and occurred before day 13 of adult life. After day 13, the age-dependent gene expression changes were relatively smaller than earlier life. Interestingly, the two biological processes of major gene expression changes are related to the two known environmental changes that increase life span in Drosophila: caloric restriction and light reduction. Our findings suggest that light signaling and energy metabolism may be important biological processes affected by aging and be interesting targets for the further investigation related to the longevity in Drosophila.

Original languageEnglish
Pages (from-to)1083-1091
Number of pages9
JournalNeurobiology of Aging
Volume26
Issue number7
DOIs
Publication statusPublished - 2005 Jan 1

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Drosophila
Head
Gene Expression
Biological Phenomena
Microarray Analysis
Light
Energy Metabolism
Genes
Molecular Sequence Annotation
Caloric Restriction
Body Regions
Gene Ontology
Oxidative Phosphorylation
Gene Expression Profiling
Protons
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Kim, S. N., Rhee, J. H., Song, Y. H., Park, D. Y., Hwang, M., Lee, S. L., ... Kim-Ha, J. (2005). Age-dependent changes of gene expression in the Drosophila head. Neurobiology of Aging, 26(7), 1083-1091. https://doi.org/10.1016/j.neurobiolaging.2004.06.017
Kim, Se Nyun ; Rhee, Ji Hwan ; Song, Young Hwa ; Park, Dong Yoon ; Hwang, Mina ; Lee, Sung Ll ; Kim, Ja Eun ; Gim, Byung Soo ; Yoon, Jeong Ho ; Kim, Young-Joon ; Kim-Ha, Jeongsil. / Age-dependent changes of gene expression in the Drosophila head. In: Neurobiology of Aging. 2005 ; Vol. 26, No. 7. pp. 1083-1091.
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Kim, SN, Rhee, JH, Song, YH, Park, DY, Hwang, M, Lee, SL, Kim, JE, Gim, BS, Yoon, JH, Kim, Y-J & Kim-Ha, J 2005, 'Age-dependent changes of gene expression in the Drosophila head', Neurobiology of Aging, vol. 26, no. 7, pp. 1083-1091. https://doi.org/10.1016/j.neurobiolaging.2004.06.017

Age-dependent changes of gene expression in the Drosophila head. / Kim, Se Nyun; Rhee, Ji Hwan; Song, Young Hwa; Park, Dong Yoon; Hwang, Mina; Lee, Sung Ll; Kim, Ja Eun; Gim, Byung Soo; Yoon, Jeong Ho; Kim, Young-Joon; Kim-Ha, Jeongsil.

In: Neurobiology of Aging, Vol. 26, No. 7, 01.01.2005, p. 1083-1091.

Research output: Contribution to journalArticle

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AU - Kim, Ja Eun

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AU - Kim, Young-Joon

AU - Kim-Ha, Jeongsil

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N2 - Previous gene expression profiling studies in Drosophila have provided clues for understanding the aging process at the gene expression level. For a detailed understanding, studies of specific regions of the body are necessary. We therefore employed microarray analysis to examine gene expression changes in the Drosophila head during aging. Six hundred and eighty-four of the 5405 genes present in the microarray showed significant age-dependent changes as determined by significance analysis of microarray (SAM) (q < 0.05). The biological significance of the changes was analyzed using the gene annotations provided by the Gene Ontology Consortium. Major changes involved genes affecting energy metabolism (proton transport, energy pathways, oxidative phosphorylation) and neuronal function, especially responses to light. Genes involved in protein catabolism and several other metabolic processes also showed age-dependent changes. Most of the changes were reductions in gene expression and occurred before day 13 of adult life. After day 13, the age-dependent gene expression changes were relatively smaller than earlier life. Interestingly, the two biological processes of major gene expression changes are related to the two known environmental changes that increase life span in Drosophila: caloric restriction and light reduction. Our findings suggest that light signaling and energy metabolism may be important biological processes affected by aging and be interesting targets for the further investigation related to the longevity in Drosophila.

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