Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice

Soo Min Cho, Sejin Lee, Seung Hoon Yang, Hye Yun Kim, Michael Jisoo Lee, Hyunjin Vincent Kim, Jiyoon Kim, Seungyeop Baek, Jin Yun, Dohee Kim, Yun Kyung Kim, Yakdol Cho, Jiwan Woo, Tae Song Kim, YoungSoo Kim

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Abstract

Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF Aβ(1-42) levels until plaques form in transgenic mice's brains and that the plasma Aβ concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.

Original languageEnglish
Article number20185
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 2

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Amyloid Plaques
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Brain
Biomarkers
Transgenic Mice

All Science Journal Classification (ASJC) codes

  • General

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Cho, Soo Min ; Lee, Sejin ; Yang, Seung Hoon ; Kim, Hye Yun ; Lee, Michael Jisoo ; Kim, Hyunjin Vincent ; Kim, Jiyoon ; Baek, Seungyeop ; Yun, Jin ; Kim, Dohee ; Kim, Yun Kyung ; Cho, Yakdol ; Woo, Jiwan ; Kim, Tae Song ; Kim, YoungSoo. / Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice. In: Scientific reports. 2016 ; Vol. 6.
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abstract = "Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF Aβ(1-42) levels until plaques form in transgenic mice's brains and that the plasma Aβ concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.",
author = "Cho, {Soo Min} and Sejin Lee and Yang, {Seung Hoon} and Kim, {Hye Yun} and Lee, {Michael Jisoo} and Kim, {Hyunjin Vincent} and Jiyoon Kim and Seungyeop Baek and Jin Yun and Dohee Kim and Kim, {Yun Kyung} and Yakdol Cho and Jiwan Woo and Kim, {Tae Song} and YoungSoo Kim",
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Cho, SM, Lee, S, Yang, SH, Kim, HY, Lee, MJ, Kim, HV, Kim, J, Baek, S, Yun, J, Kim, D, Kim, YK, Cho, Y, Woo, J, Kim, TS & Kim, Y 2016, 'Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice', Scientific reports, vol. 6, 20185. https://doi.org/10.1038/srep20185

Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice. / Cho, Soo Min; Lee, Sejin; Yang, Seung Hoon; Kim, Hye Yun; Lee, Michael Jisoo; Kim, Hyunjin Vincent; Kim, Jiyoon; Baek, Seungyeop; Yun, Jin; Kim, Dohee; Kim, Yun Kyung; Cho, Yakdol; Woo, Jiwan; Kim, Tae Song; Kim, YoungSoo.

In: Scientific reports, Vol. 6, 20185, 02.02.2016.

Research output: Contribution to journalArticle

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AU - Cho, Soo Min

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AU - Kim, Hye Yun

AU - Lee, Michael Jisoo

AU - Kim, Hyunjin Vincent

AU - Kim, Jiyoon

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AU - Yun, Jin

AU - Kim, Dohee

AU - Kim, Yun Kyung

AU - Cho, Yakdol

AU - Woo, Jiwan

AU - Kim, Tae Song

AU - Kim, YoungSoo

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