Age-distinct predictors of symptomatic cervicocephalic atherosclerosis

Oh Young Bang, Jeffrey L. Saver, David S. Liebeskind, philhyu Lee, Seung Soo Sheen, Sa Rah Yoon, Susan W. Yun, Gyeong Moon Kim, Chin Sang Chung, Kwang Ho Lee, Bruce Ovbiagele

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Little is known about whether vascular risk factors predispose to atherosclerotic stroke depending on age. We evaluated predictors of large vessel atherosclerotic stroke (LVAS) stratified by age in two geographically and racially distinct study populations. Methods: Data collected over a 4-year period in prospectively maintained registries on 3,053 subjects with ischemic cerebrovascular events were analyzed: 1,982 patients from a hospital in South Korea and 1,071 patients admitted to a hospital in Los Angeles, Calif., USA. Independent vascular risk factor associations with LVAS mechanism were evaluated in three groups stratified by age (years) at symptom onset: young (≤50 years), older (51-75 years), and oldest (>75 years). Results: Altogether at both study sites, 972 (31.8%) patients had LVAS mechanism, of whom 391 (40.2%) were female. Risk factor profiles were not significantly different between LVAS versus other stroke mechanisms. Among young patients, after adjusting for covariates, current smoking was the only predictor of atherosclerotic stroke at both Korean (OR 2.04; 95% CI: 1.13-3.69) and Californian sites (OR 4.78, 95% CI 1.54-14.89), while the metabolic syndrome was the only predictor of atherosclerotic stroke among the older patients (OR 1.58, 95% CI 1.17-2.12 for Korean; OR 1.75, 95% CI 1.07-2.84 for Californian), but not in the young or oldest groups. Conclusions: Across race and region, the estimated impact of vascular risk factors for LVAS varies by age, and this is most prominently seen among persons of less than 76 years of age. Some risk factors have an early effect (smoking) and others an effect that plays out over time.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalCerebrovascular Diseases
Volume27
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Atherosclerosis
Stroke
Smoking
Republic of Korea
Los Angeles
Registries
Age Groups
Population
vascular factor

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Bang, O. Y., Saver, J. L., Liebeskind, D. S., Lee, P., Sheen, S. S., Yoon, S. R., ... Ovbiagele, B. (2009). Age-distinct predictors of symptomatic cervicocephalic atherosclerosis. Cerebrovascular Diseases, 27(1), 13-21. https://doi.org/10.1159/000172629
Bang, Oh Young ; Saver, Jeffrey L. ; Liebeskind, David S. ; Lee, philhyu ; Sheen, Seung Soo ; Yoon, Sa Rah ; Yun, Susan W. ; Kim, Gyeong Moon ; Chung, Chin Sang ; Lee, Kwang Ho ; Ovbiagele, Bruce. / Age-distinct predictors of symptomatic cervicocephalic atherosclerosis. In: Cerebrovascular Diseases. 2009 ; Vol. 27, No. 1. pp. 13-21.
@article{48ed5d17bc6246c28f2afda3f234211f,
title = "Age-distinct predictors of symptomatic cervicocephalic atherosclerosis",
abstract = "Background: Little is known about whether vascular risk factors predispose to atherosclerotic stroke depending on age. We evaluated predictors of large vessel atherosclerotic stroke (LVAS) stratified by age in two geographically and racially distinct study populations. Methods: Data collected over a 4-year period in prospectively maintained registries on 3,053 subjects with ischemic cerebrovascular events were analyzed: 1,982 patients from a hospital in South Korea and 1,071 patients admitted to a hospital in Los Angeles, Calif., USA. Independent vascular risk factor associations with LVAS mechanism were evaluated in three groups stratified by age (years) at symptom onset: young (≤50 years), older (51-75 years), and oldest (>75 years). Results: Altogether at both study sites, 972 (31.8{\%}) patients had LVAS mechanism, of whom 391 (40.2{\%}) were female. Risk factor profiles were not significantly different between LVAS versus other stroke mechanisms. Among young patients, after adjusting for covariates, current smoking was the only predictor of atherosclerotic stroke at both Korean (OR 2.04; 95{\%} CI: 1.13-3.69) and Californian sites (OR 4.78, 95{\%} CI 1.54-14.89), while the metabolic syndrome was the only predictor of atherosclerotic stroke among the older patients (OR 1.58, 95{\%} CI 1.17-2.12 for Korean; OR 1.75, 95{\%} CI 1.07-2.84 for Californian), but not in the young or oldest groups. Conclusions: Across race and region, the estimated impact of vascular risk factors for LVAS varies by age, and this is most prominently seen among persons of less than 76 years of age. Some risk factors have an early effect (smoking) and others an effect that plays out over time.",
author = "Bang, {Oh Young} and Saver, {Jeffrey L.} and Liebeskind, {David S.} and philhyu Lee and Sheen, {Seung Soo} and Yoon, {Sa Rah} and Yun, {Susan W.} and Kim, {Gyeong Moon} and Chung, {Chin Sang} and Lee, {Kwang Ho} and Bruce Ovbiagele",
year = "2009",
month = "1",
day = "1",
doi = "10.1159/000172629",
language = "English",
volume = "27",
pages = "13--21",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "1",

}

Bang, OY, Saver, JL, Liebeskind, DS, Lee, P, Sheen, SS, Yoon, SR, Yun, SW, Kim, GM, Chung, CS, Lee, KH & Ovbiagele, B 2009, 'Age-distinct predictors of symptomatic cervicocephalic atherosclerosis', Cerebrovascular Diseases, vol. 27, no. 1, pp. 13-21. https://doi.org/10.1159/000172629

Age-distinct predictors of symptomatic cervicocephalic atherosclerosis. / Bang, Oh Young; Saver, Jeffrey L.; Liebeskind, David S.; Lee, philhyu; Sheen, Seung Soo; Yoon, Sa Rah; Yun, Susan W.; Kim, Gyeong Moon; Chung, Chin Sang; Lee, Kwang Ho; Ovbiagele, Bruce.

In: Cerebrovascular Diseases, Vol. 27, No. 1, 01.01.2009, p. 13-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-distinct predictors of symptomatic cervicocephalic atherosclerosis

AU - Bang, Oh Young

AU - Saver, Jeffrey L.

AU - Liebeskind, David S.

AU - Lee, philhyu

AU - Sheen, Seung Soo

AU - Yoon, Sa Rah

AU - Yun, Susan W.

AU - Kim, Gyeong Moon

AU - Chung, Chin Sang

AU - Lee, Kwang Ho

AU - Ovbiagele, Bruce

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: Little is known about whether vascular risk factors predispose to atherosclerotic stroke depending on age. We evaluated predictors of large vessel atherosclerotic stroke (LVAS) stratified by age in two geographically and racially distinct study populations. Methods: Data collected over a 4-year period in prospectively maintained registries on 3,053 subjects with ischemic cerebrovascular events were analyzed: 1,982 patients from a hospital in South Korea and 1,071 patients admitted to a hospital in Los Angeles, Calif., USA. Independent vascular risk factor associations with LVAS mechanism were evaluated in three groups stratified by age (years) at symptom onset: young (≤50 years), older (51-75 years), and oldest (>75 years). Results: Altogether at both study sites, 972 (31.8%) patients had LVAS mechanism, of whom 391 (40.2%) were female. Risk factor profiles were not significantly different between LVAS versus other stroke mechanisms. Among young patients, after adjusting for covariates, current smoking was the only predictor of atherosclerotic stroke at both Korean (OR 2.04; 95% CI: 1.13-3.69) and Californian sites (OR 4.78, 95% CI 1.54-14.89), while the metabolic syndrome was the only predictor of atherosclerotic stroke among the older patients (OR 1.58, 95% CI 1.17-2.12 for Korean; OR 1.75, 95% CI 1.07-2.84 for Californian), but not in the young or oldest groups. Conclusions: Across race and region, the estimated impact of vascular risk factors for LVAS varies by age, and this is most prominently seen among persons of less than 76 years of age. Some risk factors have an early effect (smoking) and others an effect that plays out over time.

AB - Background: Little is known about whether vascular risk factors predispose to atherosclerotic stroke depending on age. We evaluated predictors of large vessel atherosclerotic stroke (LVAS) stratified by age in two geographically and racially distinct study populations. Methods: Data collected over a 4-year period in prospectively maintained registries on 3,053 subjects with ischemic cerebrovascular events were analyzed: 1,982 patients from a hospital in South Korea and 1,071 patients admitted to a hospital in Los Angeles, Calif., USA. Independent vascular risk factor associations with LVAS mechanism were evaluated in three groups stratified by age (years) at symptom onset: young (≤50 years), older (51-75 years), and oldest (>75 years). Results: Altogether at both study sites, 972 (31.8%) patients had LVAS mechanism, of whom 391 (40.2%) were female. Risk factor profiles were not significantly different between LVAS versus other stroke mechanisms. Among young patients, after adjusting for covariates, current smoking was the only predictor of atherosclerotic stroke at both Korean (OR 2.04; 95% CI: 1.13-3.69) and Californian sites (OR 4.78, 95% CI 1.54-14.89), while the metabolic syndrome was the only predictor of atherosclerotic stroke among the older patients (OR 1.58, 95% CI 1.17-2.12 for Korean; OR 1.75, 95% CI 1.07-2.84 for Californian), but not in the young or oldest groups. Conclusions: Across race and region, the estimated impact of vascular risk factors for LVAS varies by age, and this is most prominently seen among persons of less than 76 years of age. Some risk factors have an early effect (smoking) and others an effect that plays out over time.

UR - http://www.scopus.com/inward/record.url?scp=56149113308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56149113308&partnerID=8YFLogxK

U2 - 10.1159/000172629

DO - 10.1159/000172629

M3 - Article

VL - 27

SP - 13

EP - 21

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 1

ER -