Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus

In Koo Hwang; Ki Yeon Yoo; Sun Shin Yi; Young Guen Kwon; Young Keun Ahn; Je Kyung Seong; In Se Lee; Yeo Sung Yoon; Moo Ho Won

doi:10.1007/s11064-007-9528-1

Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus

In Koo Hwang, Ki Yeon Yoo, Sun Shin Yi, Young Guen Kwon, Young Keun Ahn, Je Kyung Seong, In Se Lee, Yeo Sung Yoon, Moo Ho Won

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.

Original language	English
Pages (from-to)	867-872
Number of pages	6
Journal	Neurochemical Research
Volume	33
Issue number	5
DOIs	https://doi.org/10.1007/s11064-007-9528-1
Publication status	Published - 2008 May

Bibliographical note

Funding Information:
Acknowledgements The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This work was supported by the stem cell research program of Ministry of Science & Technology, grants (M10641450001-06N4145-00110).

All Science Journal Classification (ASJC) codes

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1007/s11064-007-9528-1

Cite this

@article{ef9ff9b1fa114b369ac0d167d66bd848,

title = "Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus",

abstract = "In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.",

author = "Hwang, {In Koo} and Yoo, {Ki Yeon} and Yi, {Sun Shin} and Kwon, {Young Guen} and Ahn, {Young Keun} and Seong, {Je Kyung} and Lee, {In Se} and Yoon, {Yeo Sung} and Won, {Moo Ho}",

note = "Funding Information: Acknowledgements The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This work was supported by the stem cell research program of Ministry of Science & Technology, grants (M10641450001-06N4145-00110).",

year = "2008",

month = may,

doi = "10.1007/s11064-007-9528-1",

language = "English",

volume = "33",

pages = "867--872",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer New York",

number = "5",

}

TY - JOUR

T1 - Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus

AU - Hwang, In Koo

AU - Yoo, Ki Yeon

AU - Yi, Sun Shin

AU - Kwon, Young Guen

AU - Ahn, Young Keun

AU - Seong, Je Kyung

AU - Lee, In Se

AU - Yoon, Yeo Sung

AU - Won, Moo Ho

N1 - Funding Information: Acknowledgements The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This work was supported by the stem cell research program of Ministry of Science & Technology, grants (M10641450001-06N4145-00110).

PY - 2008/5

Y1 - 2008/5

N2 - In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.

AB - In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.

UR - http://www.scopus.com/inward/record.url?scp=41049110042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41049110042&partnerID=8YFLogxK

U2 - 10.1007/s11064-007-9528-1

DO - 10.1007/s11064-007-9528-1

M3 - Article

C2 - 17987384

AN - SCOPUS:41049110042

SN - 0364-3190

VL - 33

SP - 867

EP - 872

JO - Neurochemical Research

JF - Neurochemical Research

IS - 5

ER -

Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this