Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus

In Koo Hwang, Ki Yeon Yoo, Sun Shin Yi, Young Guen Kwon, Young Keun Ahn, Je Kyung Seong, In Se Lee, Yeo Sung Yoon, Moo Ho Won

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.

Original languageEnglish
Pages (from-to)867-872
Number of pages6
JournalNeurochemical Research
Volume33
Issue number5
DOIs
Publication statusPublished - 2008 May

Bibliographical note

Funding Information:
Acknowledgements The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This work was supported by the stem cell research program of Ministry of Science & Technology, grants (M10641450001-06N4145-00110).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Age-related differentiation in newly generated DCX immunoreactive neurons in the subgranular zone of the gerbil dentate gyrus'. Together they form a unique fingerprint.

Cite this