Age-related epigenetic regulation in the brain and its role in neuronal diseases

Jeongsil Kim-Ha; Young Joon Kim

doi:10.5483/BMBRep.2016.49.12.184

Age-related epigenetic regulation in the brain and its role in neuronal diseases

Jeongsil Kim-Ha, Young Joon Kim

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain.

Original language	English
Pages (from-to)	671-680
Number of pages	10
Journal	BMB reports
Volume	49
Issue number	12
DOIs	https://doi.org/10.5483/BMBRep.2016.49.12.184
Publication status	Published - 2016

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2012M3A9B4028272), and Collaborative Genome Program for Fostering New Post-Genome industry through the National Research Foundation of Korea (NRF) funded by the Ministry of Science ICT and Future Planning (grant number: 2015M3C9A4053251 and 2016M3C9A4921712) to Y-J Kim and by the Mid-Career Researcher Program (NRF-2012R1A2A2A01010176) and Basic Science Research Program (NRF-2011-0010593) of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning to J. Kim-Ha. We thank JB Moon for his help with figures.

Publisher Copyright:
© 2016 by the The Korean Society for Biochemistry and Molecular Biology.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

Access to Document

10.5483/BMBRep.2016.49.12.184

Cite this

@article{7ba249fdb6e4430987c71042faa28199,

title = "Age-related epigenetic regulation in the brain and its role in neuronal diseases",

abstract = "Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain.",

author = "Jeongsil Kim-Ha and Kim, {Young Joon}",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2012M3A9B4028272), and Collaborative Genome Program for Fostering New Post-Genome industry through the National Research Foundation of Korea (NRF) funded by the Ministry of Science ICT and Future Planning (grant number: 2015M3C9A4053251 and 2016M3C9A4921712) to Y-J Kim and by the Mid-Career Researcher Program (NRF-2012R1A2A2A01010176) and Basic Science Research Program (NRF-2011-0010593) of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning to J. Kim-Ha. We thank JB Moon for his help with figures. Publisher Copyright: {\textcopyright} 2016 by the The Korean Society for Biochemistry and Molecular Biology.",

year = "2016",

doi = "10.5483/BMBRep.2016.49.12.184",

language = "English",

volume = "49",

pages = "671--680",

journal = "BMB Reports",

issn = "1976-6696",

publisher = "The Biochemical Society of the Republic of Korea",

number = "12",

}

TY - JOUR

T1 - Age-related epigenetic regulation in the brain and its role in neuronal diseases

AU - Kim-Ha, Jeongsil

AU - Kim, Young Joon

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2012M3A9B4028272), and Collaborative Genome Program for Fostering New Post-Genome industry through the National Research Foundation of Korea (NRF) funded by the Ministry of Science ICT and Future Planning (grant number: 2015M3C9A4053251 and 2016M3C9A4921712) to Y-J Kim and by the Mid-Career Researcher Program (NRF-2012R1A2A2A01010176) and Basic Science Research Program (NRF-2011-0010593) of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning to J. Kim-Ha. We thank JB Moon for his help with figures. Publisher Copyright: © 2016 by the The Korean Society for Biochemistry and Molecular Biology.

PY - 2016

Y1 - 2016

N2 - Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain.

AB - Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain.

UR - http://www.scopus.com/inward/record.url?scp=85009186348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009186348&partnerID=8YFLogxK

U2 - 10.5483/BMBRep.2016.49.12.184

DO - 10.5483/BMBRep.2016.49.12.184

M3 - Review article

C2 - 27866512

AN - SCOPUS:85009186348

SN - 1976-6696

VL - 49

SP - 671

EP - 680

JO - BMB Reports

JF - BMB Reports

IS - 12

ER -

Age-related epigenetic regulation in the brain and its role in neuronal diseases

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this