Age-specific determinants of pulse wave velocity among metabolic syndrome components, inflammatory markers, and oxidative stress

Minkyung Kim, Minjoo Kim, Hye Jin Yoo, Seung Yeon Lee, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. Methods: A total of 4,318 subjects were divided into 4 groups: 19–34 y (n=687), 35–44 y (n= 1,413), 45–54 y (n=1,384), and 55–79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F (8-epi-PGF), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19–34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35–44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45–54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55–79 y group. Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalJournal of Atherosclerosis and Thrombosis
Volume25
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

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Pulse Wave Analysis
Oxidative stress
Oxidative Stress
Ankle
C-Reactive Protein
Vascular Stiffness
Body Mass Index
Arm
Glucose
Fasting
Triglycerides
Stiffness
Blood Pressure
Dinoprost
Age Factors
Blood pressure
Waist Circumference
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Kim, Minkyung ; Kim, Minjoo ; Yoo, Hye Jin ; Lee, Seung Yeon ; Lee, Sang Hyun ; Lee, Jong Ho. / Age-specific determinants of pulse wave velocity among metabolic syndrome components, inflammatory markers, and oxidative stress. In: Journal of Atherosclerosis and Thrombosis. 2018 ; Vol. 25, No. 2. pp. 178-185.
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abstract = "Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. Methods: A total of 4,318 subjects were divided into 4 groups: 19–34 y (n=687), 35–44 y (n= 1,413), 45–54 y (n=1,384), and 55–79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F2α (8-epi-PGF2α), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19–34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35–44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45–54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55–79 y group. Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.",
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Age-specific determinants of pulse wave velocity among metabolic syndrome components, inflammatory markers, and oxidative stress. / Kim, Minkyung; Kim, Minjoo; Yoo, Hye Jin; Lee, Seung Yeon; Lee, Sang Hyun; Lee, Jong Ho.

In: Journal of Atherosclerosis and Thrombosis, Vol. 25, No. 2, 01.01.2018, p. 178-185.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-specific determinants of pulse wave velocity among metabolic syndrome components, inflammatory markers, and oxidative stress

AU - Kim, Minkyung

AU - Kim, Minjoo

AU - Yoo, Hye Jin

AU - Lee, Seung Yeon

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. Methods: A total of 4,318 subjects were divided into 4 groups: 19–34 y (n=687), 35–44 y (n= 1,413), 45–54 y (n=1,384), and 55–79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F2α (8-epi-PGF2α), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19–34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35–44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45–54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55–79 y group. Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

AB - Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. Methods: A total of 4,318 subjects were divided into 4 groups: 19–34 y (n=687), 35–44 y (n= 1,413), 45–54 y (n=1,384), and 55–79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F2α (8-epi-PGF2α), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19–34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35–44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45–54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55–79 y group. Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

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