Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men

Youngdeuk Choi, Dae Ryong Kang, Chung Mo Nam, Young Sig Kim, Soung Yong Cho, Se Joong Kim, In Rae Cho, Jin Seon Cho, Sung Joon Hong, Won Sik Ham

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: The serum prostate-specific antigen (PSA) level varies widely among different races and increases with age. In this study, we evaluated the variation in serum PSA levels in a multicenter study population to determine a standard age-specific PSA reference range for Korean men without clinically evident prostate cancer. Methods: We retrospectively analyzed 120,439 Korean men, ranging in age from 30 to 79 years, whose serum PSA levels were measured at one of eight referral hospitals from November 1998 to July 2005. Results: Our recommended age-specific reference ranges (95th percentile) of serum PSA levels for Korean men were 0.32 to 1.88 ng/mL for men 30 to 39 years, 0.30 to 1.92 ng/mL for men 40 to 49 years, 0.30 to 2.37 ng/mL for men 50 to 59 years, 0.31 to 3.56 ng/mL for men 60 to 69 years, and 0.30 to 5.19 ng/mL for men 70 to 79 years old. The serum PSA level increased annually, corresponding to an increase of 0.0023 ng/mL for men in their 40s, 0.0175 ng/mL for men in their 50s, 0.0499 ng/mL for men in their 60s, and 0.0398 ng/mL for men in their 70s, with a steep increase for men in their 50s and the largest increase in men older than 60 years. Conclusions: The results of our study have shown that the age-specific reference ranges (95th percentile) for serum PSA levels in Korean men are lower than those for white men. Our newly proposed age-specific reference ranges from this multicenter study will be more valuable in the interpretation of PSA data for Korean men.

Original languageEnglish
Pages (from-to)1113-1116
Number of pages4
JournalUrology
Volume70
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Prostate-Specific Antigen
Reference Values
Serum
Multicenter Studies

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Choi, Y., Kang, D. R., Nam, C. M., Kim, Y. S., Cho, S. Y., Kim, S. J., ... Ham, W. S. (2007). Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men. Urology, 70(6), 1113-1116. https://doi.org/10.1016/j.urology.2007.07.063
Choi, Youngdeuk ; Kang, Dae Ryong ; Nam, Chung Mo ; Kim, Young Sig ; Cho, Soung Yong ; Kim, Se Joong ; Cho, In Rae ; Cho, Jin Seon ; Hong, Sung Joon ; Ham, Won Sik. / Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men. In: Urology. 2007 ; Vol. 70, No. 6. pp. 1113-1116.
@article{a6d59f0931654c198e0318c163ad4592,
title = "Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men",
abstract = "Objectives: The serum prostate-specific antigen (PSA) level varies widely among different races and increases with age. In this study, we evaluated the variation in serum PSA levels in a multicenter study population to determine a standard age-specific PSA reference range for Korean men without clinically evident prostate cancer. Methods: We retrospectively analyzed 120,439 Korean men, ranging in age from 30 to 79 years, whose serum PSA levels were measured at one of eight referral hospitals from November 1998 to July 2005. Results: Our recommended age-specific reference ranges (95th percentile) of serum PSA levels for Korean men were 0.32 to 1.88 ng/mL for men 30 to 39 years, 0.30 to 1.92 ng/mL for men 40 to 49 years, 0.30 to 2.37 ng/mL for men 50 to 59 years, 0.31 to 3.56 ng/mL for men 60 to 69 years, and 0.30 to 5.19 ng/mL for men 70 to 79 years old. The serum PSA level increased annually, corresponding to an increase of 0.0023 ng/mL for men in their 40s, 0.0175 ng/mL for men in their 50s, 0.0499 ng/mL for men in their 60s, and 0.0398 ng/mL for men in their 70s, with a steep increase for men in their 50s and the largest increase in men older than 60 years. Conclusions: The results of our study have shown that the age-specific reference ranges (95th percentile) for serum PSA levels in Korean men are lower than those for white men. Our newly proposed age-specific reference ranges from this multicenter study will be more valuable in the interpretation of PSA data for Korean men.",
author = "Youngdeuk Choi and Kang, {Dae Ryong} and Nam, {Chung Mo} and Kim, {Young Sig} and Cho, {Soung Yong} and Kim, {Se Joong} and Cho, {In Rae} and Cho, {Jin Seon} and Hong, {Sung Joon} and Ham, {Won Sik}",
year = "2007",
month = "12",
day = "1",
doi = "10.1016/j.urology.2007.07.063",
language = "English",
volume = "70",
pages = "1113--1116",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

Choi, Y, Kang, DR, Nam, CM, Kim, YS, Cho, SY, Kim, SJ, Cho, IR, Cho, JS, Hong, SJ & Ham, WS 2007, 'Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men', Urology, vol. 70, no. 6, pp. 1113-1116. https://doi.org/10.1016/j.urology.2007.07.063

Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men. / Choi, Youngdeuk; Kang, Dae Ryong; Nam, Chung Mo; Kim, Young Sig; Cho, Soung Yong; Kim, Se Joong; Cho, In Rae; Cho, Jin Seon; Hong, Sung Joon; Ham, Won Sik.

In: Urology, Vol. 70, No. 6, 01.12.2007, p. 1113-1116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-Specific Prostate-Specific Antigen Reference Ranges in Korean Men

AU - Choi, Youngdeuk

AU - Kang, Dae Ryong

AU - Nam, Chung Mo

AU - Kim, Young Sig

AU - Cho, Soung Yong

AU - Kim, Se Joong

AU - Cho, In Rae

AU - Cho, Jin Seon

AU - Hong, Sung Joon

AU - Ham, Won Sik

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Objectives: The serum prostate-specific antigen (PSA) level varies widely among different races and increases with age. In this study, we evaluated the variation in serum PSA levels in a multicenter study population to determine a standard age-specific PSA reference range for Korean men without clinically evident prostate cancer. Methods: We retrospectively analyzed 120,439 Korean men, ranging in age from 30 to 79 years, whose serum PSA levels were measured at one of eight referral hospitals from November 1998 to July 2005. Results: Our recommended age-specific reference ranges (95th percentile) of serum PSA levels for Korean men were 0.32 to 1.88 ng/mL for men 30 to 39 years, 0.30 to 1.92 ng/mL for men 40 to 49 years, 0.30 to 2.37 ng/mL for men 50 to 59 years, 0.31 to 3.56 ng/mL for men 60 to 69 years, and 0.30 to 5.19 ng/mL for men 70 to 79 years old. The serum PSA level increased annually, corresponding to an increase of 0.0023 ng/mL for men in their 40s, 0.0175 ng/mL for men in their 50s, 0.0499 ng/mL for men in their 60s, and 0.0398 ng/mL for men in their 70s, with a steep increase for men in their 50s and the largest increase in men older than 60 years. Conclusions: The results of our study have shown that the age-specific reference ranges (95th percentile) for serum PSA levels in Korean men are lower than those for white men. Our newly proposed age-specific reference ranges from this multicenter study will be more valuable in the interpretation of PSA data for Korean men.

AB - Objectives: The serum prostate-specific antigen (PSA) level varies widely among different races and increases with age. In this study, we evaluated the variation in serum PSA levels in a multicenter study population to determine a standard age-specific PSA reference range for Korean men without clinically evident prostate cancer. Methods: We retrospectively analyzed 120,439 Korean men, ranging in age from 30 to 79 years, whose serum PSA levels were measured at one of eight referral hospitals from November 1998 to July 2005. Results: Our recommended age-specific reference ranges (95th percentile) of serum PSA levels for Korean men were 0.32 to 1.88 ng/mL for men 30 to 39 years, 0.30 to 1.92 ng/mL for men 40 to 49 years, 0.30 to 2.37 ng/mL for men 50 to 59 years, 0.31 to 3.56 ng/mL for men 60 to 69 years, and 0.30 to 5.19 ng/mL for men 70 to 79 years old. The serum PSA level increased annually, corresponding to an increase of 0.0023 ng/mL for men in their 40s, 0.0175 ng/mL for men in their 50s, 0.0499 ng/mL for men in their 60s, and 0.0398 ng/mL for men in their 70s, with a steep increase for men in their 50s and the largest increase in men older than 60 years. Conclusions: The results of our study have shown that the age-specific reference ranges (95th percentile) for serum PSA levels in Korean men are lower than those for white men. Our newly proposed age-specific reference ranges from this multicenter study will be more valuable in the interpretation of PSA data for Korean men.

UR - http://www.scopus.com/inward/record.url?scp=37449030913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37449030913&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2007.07.063

DO - 10.1016/j.urology.2007.07.063

M3 - Article

C2 - 18158029

AN - SCOPUS:37449030913

VL - 70

SP - 1113

EP - 1116

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -