Age-specific reference ranges for serum prostate-specific antigen in Korean men

Hyung Jin Jeon, Young Sik Kim, Dae Ryeong Kang, Chung Mo Nam, Chun Il Kim, Do Hwan Seong, Se Joong Kim, Sang Hyeon Cheon, In Rae Cho, Jin Seon Cho, Sung Joon Hong, Young Deuk Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: The level of serum prostate-specific antigen (PSA) varies according to both age and race. It is known that the level of PSA increases with age, and that Asians have a lower incidence of prostate cancer and levels of PSA than Caucasians. In this study, the variation in the serum PSA level in samples collected from general populations were used to find an actual standard age-specific PSA reference range for Koreans. Materials and Methods: Patients who received serum PSA level check-ups, between November 1998 and July 2005, at 8 domestic hospitals, were selected for the investigation. The PSA levels of 120,439 adult males, aged between 30 and 80 years, were measured, and those lower than 10ng/ml were analyzed. To estimate the increase in the level of serum PSA according to age, a simple linear regression analysis was carried out. Results: The mean PSA level reference ranges according to age were 1.88, 1.92, 2.37, 3.56 and 5.19ng/ml for those in their thirties, forties, fifties, sixties and seventies, respectively. The rates of PSA change were 0.0023, 0.0175 and 0.0499 for those in their forties, fifties and sixties, respectively, indicating the rates of PSA level change increase steady with age, but these increases are greater for those in their fifties and most severe after their sixties. The level of age-specific PSA reference in Korean men was lower than that of men from Western countries. Conclusions: The age-specific PSA reference levels, as found in pre-existing literature, showed differences between races, with the overall reference levels being low for domestic data. The standard reference level of age-specific PSA for the screening of prostate cancer may be lower in Korean men than those from Western countries.

Original languageEnglish
Pages (from-to)586-590
Number of pages5
JournalKorean Journal of Urology
Volume47
Issue number6
DOIs
Publication statusPublished - 2006 Jun

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Prostate-Specific Antigen
Reference Values
Serum
Prostatic Neoplasms
Linear Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Jeon, Hyung Jin ; Kim, Young Sik ; Kang, Dae Ryeong ; Nam, Chung Mo ; Kim, Chun Il ; Seong, Do Hwan ; Kim, Se Joong ; Cheon, Sang Hyeon ; Cho, In Rae ; Cho, Jin Seon ; Hong, Sung Joon ; Choi, Young Deuk. / Age-specific reference ranges for serum prostate-specific antigen in Korean men. In: Korean Journal of Urology. 2006 ; Vol. 47, No. 6. pp. 586-590.
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title = "Age-specific reference ranges for serum prostate-specific antigen in Korean men",
abstract = "Purpose: The level of serum prostate-specific antigen (PSA) varies according to both age and race. It is known that the level of PSA increases with age, and that Asians have a lower incidence of prostate cancer and levels of PSA than Caucasians. In this study, the variation in the serum PSA level in samples collected from general populations were used to find an actual standard age-specific PSA reference range for Koreans. Materials and Methods: Patients who received serum PSA level check-ups, between November 1998 and July 2005, at 8 domestic hospitals, were selected for the investigation. The PSA levels of 120,439 adult males, aged between 30 and 80 years, were measured, and those lower than 10ng/ml were analyzed. To estimate the increase in the level of serum PSA according to age, a simple linear regression analysis was carried out. Results: The mean PSA level reference ranges according to age were 1.88, 1.92, 2.37, 3.56 and 5.19ng/ml for those in their thirties, forties, fifties, sixties and seventies, respectively. The rates of PSA change were 0.0023, 0.0175 and 0.0499 for those in their forties, fifties and sixties, respectively, indicating the rates of PSA level change increase steady with age, but these increases are greater for those in their fifties and most severe after their sixties. The level of age-specific PSA reference in Korean men was lower than that of men from Western countries. Conclusions: The age-specific PSA reference levels, as found in pre-existing literature, showed differences between races, with the overall reference levels being low for domestic data. The standard reference level of age-specific PSA for the screening of prostate cancer may be lower in Korean men than those from Western countries.",
author = "Jeon, {Hyung Jin} and Kim, {Young Sik} and Kang, {Dae Ryeong} and Nam, {Chung Mo} and Kim, {Chun Il} and Seong, {Do Hwan} and Kim, {Se Joong} and Cheon, {Sang Hyeon} and Cho, {In Rae} and Cho, {Jin Seon} and Hong, {Sung Joon} and Choi, {Young Deuk}",
year = "2006",
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Jeon, HJ, Kim, YS, Kang, DR, Nam, CM, Kim, CI, Seong, DH, Kim, SJ, Cheon, SH, Cho, IR, Cho, JS, Hong, SJ & Choi, YD 2006, 'Age-specific reference ranges for serum prostate-specific antigen in Korean men', Korean Journal of Urology, vol. 47, no. 6, pp. 586-590. https://doi.org/10.4111/kju.2006.47.6.586

Age-specific reference ranges for serum prostate-specific antigen in Korean men. / Jeon, Hyung Jin; Kim, Young Sik; Kang, Dae Ryeong; Nam, Chung Mo; Kim, Chun Il; Seong, Do Hwan; Kim, Se Joong; Cheon, Sang Hyeon; Cho, In Rae; Cho, Jin Seon; Hong, Sung Joon; Choi, Young Deuk.

In: Korean Journal of Urology, Vol. 47, No. 6, 06.2006, p. 586-590.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-specific reference ranges for serum prostate-specific antigen in Korean men

AU - Jeon, Hyung Jin

AU - Kim, Young Sik

AU - Kang, Dae Ryeong

AU - Nam, Chung Mo

AU - Kim, Chun Il

AU - Seong, Do Hwan

AU - Kim, Se Joong

AU - Cheon, Sang Hyeon

AU - Cho, In Rae

AU - Cho, Jin Seon

AU - Hong, Sung Joon

AU - Choi, Young Deuk

PY - 2006/6

Y1 - 2006/6

N2 - Purpose: The level of serum prostate-specific antigen (PSA) varies according to both age and race. It is known that the level of PSA increases with age, and that Asians have a lower incidence of prostate cancer and levels of PSA than Caucasians. In this study, the variation in the serum PSA level in samples collected from general populations were used to find an actual standard age-specific PSA reference range for Koreans. Materials and Methods: Patients who received serum PSA level check-ups, between November 1998 and July 2005, at 8 domestic hospitals, were selected for the investigation. The PSA levels of 120,439 adult males, aged between 30 and 80 years, were measured, and those lower than 10ng/ml were analyzed. To estimate the increase in the level of serum PSA according to age, a simple linear regression analysis was carried out. Results: The mean PSA level reference ranges according to age were 1.88, 1.92, 2.37, 3.56 and 5.19ng/ml for those in their thirties, forties, fifties, sixties and seventies, respectively. The rates of PSA change were 0.0023, 0.0175 and 0.0499 for those in their forties, fifties and sixties, respectively, indicating the rates of PSA level change increase steady with age, but these increases are greater for those in their fifties and most severe after their sixties. The level of age-specific PSA reference in Korean men was lower than that of men from Western countries. Conclusions: The age-specific PSA reference levels, as found in pre-existing literature, showed differences between races, with the overall reference levels being low for domestic data. The standard reference level of age-specific PSA for the screening of prostate cancer may be lower in Korean men than those from Western countries.

AB - Purpose: The level of serum prostate-specific antigen (PSA) varies according to both age and race. It is known that the level of PSA increases with age, and that Asians have a lower incidence of prostate cancer and levels of PSA than Caucasians. In this study, the variation in the serum PSA level in samples collected from general populations were used to find an actual standard age-specific PSA reference range for Koreans. Materials and Methods: Patients who received serum PSA level check-ups, between November 1998 and July 2005, at 8 domestic hospitals, were selected for the investigation. The PSA levels of 120,439 adult males, aged between 30 and 80 years, were measured, and those lower than 10ng/ml were analyzed. To estimate the increase in the level of serum PSA according to age, a simple linear regression analysis was carried out. Results: The mean PSA level reference ranges according to age were 1.88, 1.92, 2.37, 3.56 and 5.19ng/ml for those in their thirties, forties, fifties, sixties and seventies, respectively. The rates of PSA change were 0.0023, 0.0175 and 0.0499 for those in their forties, fifties and sixties, respectively, indicating the rates of PSA level change increase steady with age, but these increases are greater for those in their fifties and most severe after their sixties. The level of age-specific PSA reference in Korean men was lower than that of men from Western countries. Conclusions: The age-specific PSA reference levels, as found in pre-existing literature, showed differences between races, with the overall reference levels being low for domestic data. The standard reference level of age-specific PSA for the screening of prostate cancer may be lower in Korean men than those from Western countries.

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DO - 10.4111/kju.2006.47.6.586

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